Vitamin B12 deficiency causes a variety of symptoms in the hematologic, gastrointestinal tract, and neurologic deficit. We report rare case progressive gait disturbance, bradykinesia dysarthria which was that vitamin diagnosed as cause, improved after intramuscular cobalamin treatment. B12, homocysteine, methylmalonic acid tests are recommended for patients with even absence obvious anemia symp...

BACKGROUND Exclusive breastfeeding for 6 months is assumed to ensure adequate micronutrients for term infants. Our objective was to investigate the effects of prolonged breastfeeding on B vitamin status and neurodevelopment in 80 infants with subnormal birth weights (2000-3000 g) and examine if cobalamin supplementation may benefit motor function in infants who developed biochemical signs of im...

Background: Nutrient deficiency after malabsorptive bariatric procedure is a common phenomenon. The study aims to determine the prevalence of nutritional insufficiencies (specific with Ascorbic acid, Cobalamin, calciferol and calcium) in obese population opting for One Ananstomosis Gastric Bypass surgery (OAGB), also understand association these nutrients change Body Mass Index (BMI) surgery.&#...

OBJECTIVE To study the total number of combined analyses of methylmalonic acid (MMA) and total plasma homocysteine (tHcy) carried out during February 1998 at the Central Laboratory of Haukeland University Hospital. METHODS Laboratory data and requester comments of 2917 subjects in whom MMA was requested during February 1998, were retrieved from the laboratory information system (LIS). In 2520...

Until the 1990s, the most common recognised cause of cobalamin deficiency in adults was pernicious anaemia [1]. Thanks to progress made during the last 10-20 years in the understanding of vitamin B12 metabolism, “new” physiopathological concepts have emerged or recognized, including a controversial medical concept entitled food-cobalamin malabsorption (FCM) in Anglo-Saxon literature, also known...

Methylmalonic acid concentrations are increased in serum in vitamin B12 (cobalamin) deficiency. Here I demonstrate the successful use of anion-exchange extraction for improving newly developed analytical procedures and describe well-documented, reliable performance of this method for rapid determination of methylmalonic acid. The sorbent counter ion is formate, and the elution solvent is formic...

BACKGROUND Population-based data on the prevalence of cobalamin and folate deficiency in India are lacking. OBJECTIVE The objective was to measure the prevalence of cobalamin and folate deficiency among children aged 6-30 mo residing in a low-to-middle income community in North India. DESIGN Children aged 6-30 mo (n = 2482) were identified through a community survey in a low-to-middle socio...