BACKGROUND Previous research has indicated that children who have received treatment for leukaemia which includes cranial irradiation exhibit deficits in their ability to focus attention. It has been suggested that the use of cranial irradiation may have a role to play in long term sequelae. AIMS To investigate neuropsychological functioning among children treated for leukaemia without crania...

objective: neurocognitive deficits are now recognized as part of the fundamental disturbances and are a major determinant of functional outcome in psychosis. a cross-sectional association between cognitive deficits and poor social and occupational outcomes has been demonstrated; and treatment of cognitive impairment at the time of the first episode may have the potential to change functional ou...

In this issue of the Journal of Clinical Oncology, Lee et al present a rather unique and useful statistical interpretation of the waxing question of prophylactic cranial irradiation (PCI) for patients with small-cell lung cancer (SCLC). The concept of PCI for SCLC has its origins in the comparison of the behavior of this disease with childhood leukemia, a disease that is essentially systemic in...

Each year, approximately 200,000 patients in the United States will receive partial- or whole-brain irradiation for the treatment of primary or metastatic brain cancer. Early and delayed radiation effects are transient and reversible with modern therapeutic standards; yet, late radiation effects (≥6 months postirradiation) remain a significant risk, resulting in progressive cognitive impairment...

purpose: this study was conducted to assess cognitive impairments, depression, anxiety and quality of life among patients with brain tumor and healthy adults, comparatively. methods: a cross-sectional study was administrated on 84 brain tumor patients and 84 healthy adults measured by the mini mental state examination, beck, hamilton and sf36 questionnaires before and after 10 days of surgery. ...

The concept of CNS preventive therapy in childhood all is based on the assumption that undetectable CNS leukemia is present in most patients at the time of diagnosis, residing in that "sdnctuary site" protected by the blood-brain barrier from cytotoxic concentrations of most systemically ad­ministered antileukemic agents. Studies in the 1960s demonstrated that administration of 2400 rad cranial...