Dimeric kinesin motor proteins such as homodimeric kinesin-1, homodimeric Ncd and heterodimeric Kar3/Vik1are composed of two head domains which are connected together by a rod-shaped, coiled-coil stalk. Despite the extensive and intensive studies on structures, kinetics, dynamics and walking mechanism of the dimers, whether their coiled-coils are unwound or not during their walking on the micro...

introduction: any decrease in friction between orthodontic wire and bracket can accelerate tooth movement in the sliding technique and result in better control of anchorage. the present study was carried out to decrease this friction by coating of zinc oxide nanoparticles (zno) on orthodontic wires and porcelain brackets. materials and methods: in this in vitro study, a combination of 120 0.019...

At Bunbury Regional Hospital, we recently saw a case where Kirschner wires (K-wires), used during open reduction and internal fixation of olecranon, were propelled down the intramedullary canal intraoperatively. The K-wire was only secured unicortically. From our experience, we have developed steps to prevent this complication. First, where the wires are being used as part of a tension band wir...

Oligomerization is an important regulatory mechanism for many proteins, including oncoproteins and other pathogenic proteins. The oncoprotein Bcr-Abl relies on oligomerization via its coiled coil domain for its kinase activity, suggesting that a designed coiled coil domain with enhanced binding to Bcr-Abl and reduced self-oligomerization would be therapeutically useful. Key mutations in the coi...

We consider wire-driven parallel robot with N ≥ 4 wires that are connected at the same point on the platform. Such robot has 3 d.o.f. but it is non redundant (e.g. we cannot control the tension in the wires) as there will always be only at most 3 wires under tension simultaneously. We consider in this paper three approaches that make this robot really redundant: elasticity in the wires, using c...

This investigation measured the deactivation (unloading) force-deflection behavior of selected multistranded stainless steel orthodontic wires. The guidelines from the revised American National Standards Institute/American Dental Association Specification No. 32 for orthodontic wires (type 2, nonlinear elasticity) were used to perform a 3-point bending test to obtain data for the deactivation f...

AIMS To measure the friction force generated during sliding mechanics with conventional, self-ligating (Damon 3 mx, Smart Clip, and Time 3) and low-friction (Synergy) brackets using different archwire diameters and ligating systems in the presence of apical and buccal malalignments of the canine. METHODS An experimental setup reproducing the right buccal segment of the maxillary arch was desi...

most published results about the characteristics of niti wires are based on the mechanical laboratory tests on the as-received wires.the purpose of this study was to investigate the effect of saliva on load-deflection characteristics of superelastic niti wires.in this experimental study, 15 wires of three kinds of superelastic niti wires (sentalloy, force i and truflex) were prepared. five spec...

OBJECTIVE The aim of this in vitro study was to evaluate the deflection-force behavior of nickel-titanium (NiTi) orthodontic wires adjacent to the portion submitted to heat treatment. MATERIAL AND METHODS A total of 106 segments of NiTi wires (0.019 x 0.025-in) and heat-activated NiTi wires (0.016 x 0.022-in) from four commercial brands were tested. The segments were obtained from 80 archwire...

The coiled-coil structure is a typical hyper-secondary structure formed by the mutual intertwining of multiple alpha-helices, and is predicted as the structure of keratin of the intermediate filament by Crick in 1952 [2]. In 1988, the leucine zipper in the structure of transcription factors was found to be a form of the coiled-coil, and in succeeding years, a variety of biological applications ...