PURPOSE Procollagen I is synthesized and intracellularly degraded in corneal endothelial cells (CEC), whereas type IV and VIII collagens are secreted into Descemet's membrane. In our previous study, we demonstrated that procollagen I synthesized by CEC is improperly folded and that the molecule was largely colocalized with protein disulfide isomerase (PDI) within the endoplasmic reticulum (ER)....

“Supplementary Figure 1. Effect of activity blockade on synaptic area, levels of Homer and Bassoon, Homer-Bassoon colocalization values in three independent experiments, and the relationship between the colocalization values and synaptic properties. (A) TTX treatment does not affect the size of synaptic clusters. P > 0.05, Mann-Whitney test. (B) TTX treatment increases synaptic levels of Homer....

Multiple observations suggest that certain parasitic infections can be oncogenic. Among these, neurocysticercosis is associated with increased risk for gliomas and hematologic malignancies. We report the case of a 71-year-old woman with colocalization of a metazoan parasite, possibly cysticercosis, and a WHO grade IV neuroepithelial tumor with exclusively neuronal differentiation by immunohisto...

At the onset of X-chromosome inactivation, the vital process whereby female mammalian cells equalize X products with respect to males, the X chromosomes are colocalized along their Xic (X-inactivation center) regions. The mechanism inducing recognition and pairing of the X's remains, though, elusive. Starting from recent discoveries on the molecular factors and on the DNA sequences (the so-call...

Every chain functor A∗ (cf. appendix B below or [2] §4), admits a Lcolocalization (corollary 1.3., L a subcategory of the category on which A∗ is defined) AL∗ which (in contrast to the case of L-localizations, cf. [3]) in general does not allow a realization as a spectrum (even if A∗ stems from a spectrum itself). The [E, ]∗colocalization of A. K. Bousfield [6] is retrieved as a special case of...

On the cover: Dynamic change of the localization of FROUNT and CCR5 in CCL4-stimulated cell. Immunofluorescent staining at 20 min after stimulation detects colocalization of FROUNT (red) and CCR5 (green) in both the pseudopodial area and the inner cellular space (colocalization is white). Toda, E., Y. Terashima, T. Sato, K. Hirose, S. Kanegasaki, and K. Matsushima. 2009. FROUNT is a common regu...

Immunostimulatory cytidyl guanosyl (CpG) motifs are of great interest as cancer vaccine adjuvants. They act as potent inducers of Th1 responses, including the activation of cytotoxic CD8 T lymphocytes (CTL). Whereas animal models have provided clear evidence that CpG enhances antitumor immunity, clinical trials in humans have thus far been less successful. Applying cryosurgery as an instant in ...