Previously we reported that auraptene was a potent suppressant for matrix metalloproteinase (MMP)-7 expression in HT-29 human colon cancer cells. In the present study, we examined the effects of auraptene on MMP-2, -7, and -9 expression in colonic mucosa from dextran sulfate sodium (DSS)-induced ulcerative colitis mice. Auraptene remarkably suppressed the DSS-induced gelatinolytic activity of M...

The application of probiotics and prebiotics to the manipulation of the microbial ecology of the human colon has recently seen many scientific advances. The sequencing of probiotic genomes is providing a wealth of new information on the biology of these microorganisms. In addition, we are learning more about the interactions of probiotics with human cells and with pathogenic bacteria. An altern...

introduction: functional constipation is one of the most common gastrointestinal symptoms which could affect patients’ quality of life. the colonic transit time test could be used for determining functional constipation subtypes. the aim of our study was to determine the abnormalities of the subtypes of functional constipation using ctt. methods and materials: this cross-sectional study was per...

objective(s):the aim of this study was to prepare electrospun nanofibers of celecoxib using combination of time-dependent polymers with pectin to achieve a colon-specific drug delivery system for celecoxib. materials and methods:formulations were produced based on two multilevel 22 full factorial designs. the independent variables were the ratio of drug:time-dependent polymer (x1) and the amoun...

background: complete colonic duplication is a very rare congenital anomaly that may have different presentations according to its location and size. complete colonic duplication can occur in 15% of gastrointestinal duplication. we report two cases of complete colonic duplications, and their characteristics. case presentation: we present two patients with complete colonic duplication with differ...

Background: Prednisolone (PRD) is orally prescribed for inflammatory bowel syndrome (IBS) as the upper GIT main site of absorption; therefore, long-term PRD dosing decreases therapeutic effectiveness through systemic side effects. Objective: This work focused on formulating sustained-release alginate beads a multiparticulate system colon targeting using prednisolone to be filled in an HPMC caps...