نتایج جستجو برای: colorectal cancer cell line
تعداد نتایج: 2622543 فیلتر نتایج به سال:
Although EGFR-targeted therapy has been beneficial to colorectal cancer patients, several studies have showed this clinical benefit was restricted to patients with wild-type KRAS exon 2 colorectal cancer. Therefore, it is crucial to explore efficient treatment strategies in patients with KRAS mutations. c-Met is an emerging target for the development of therapeutics against colorectal cancer. I...
Cytotoxicity evaluation of a new series of naphthalimide derivatives against human cancer cell lines
Introduction: Cancer has been known as one the main causes of the death in the world. In recent researches, discovery of effective, selective and safe medications is a priority and emergency. In recent reports, the role of lipoxygenases (LOX) has been confirmed in neoplastic diseases. Some isoenzymes such as 5, 12 and 15 have more importance in the neoplasia. According to the efficacy of naphth...
OBJECTIVE The structural maintenance of chromosomes (SMC) 1A protein is a component of the cohesin multiprotein complex that is essential for sister chromatid cohesion. SMC1A gene mutations have been reported in colorectal cancer. This study aimed to investigate the role of SMC1A gene expression in colorectal cancer in vitro. METHODS SMC1A gene expression was silenced by lentivirus-mediated i...
Methyl-CpG-binding protein 2 (MeCP2) is a transcriptional repressor that has been implicated in tumor onset and progression. Compared with normal and other tumorous tissue, MeCP2 is highly expressed in well-differentiated adenocarcinoma and mucinous adenocarcinoma tissues, particularly at the invasion site of colorectal cancer tissues. The aim of the present study was to evaluate the potential ...
Background: Lactoferrin (Lf) is a glycoprotein, a member of the transferrin family.From ten known mechanisms of anti-cancer chemoperotecive compounds, Lf alone, has six of these functions and inhibits cancer. In this study, the effect of lactoferrin purified from bovine colostrum was studied as an anti-cancer agent on esophageal cancer cell line. Materials and Methods: Bovine colostrum were ...
Background:Digestive system is the most common type of cancer in Iran with 38 percent of the cases.The risk of this cancer is influenced by both environmental and genetic factors. Curcumin is kind of phytochemicals which is important in chemoprevention strategy, in order to slow, block, or reverse the process of carcinogenesis.Researchhave shown that the possible role of curcumin to prevent or ...
Background: Colorectal cancer (CRC) is one of the leading causes of death worldwide. Sargassum boveanum is a plant species of brown algae that is widely found in the Persian Gulf. The present study investigated the antioxidant and cytotoxic activity of the hydroalcoholic extract of Sargassum boveanum in colorectal cancer cell lines. Materials and Methods: Sargassum boveanum was collected from t...
background : essential oils are the volatile fraction of aromatic and medicinal plants created after extraction by steam or water distillation. species of the genus citrus (rutaceae) have been widely used in traditional medicine as volatile oils and are currently the subject of numerous research. citrus essential oil consists of different terpens that have antitumor activities. this study deter...
normal 0 false false false en-us x-none fa microsoftinternetexplorer4 aim : the purpose of this study was to determine the relationship of rs4444903 (egf+61a/g) snp genotype with colorectal cancer and tumor stage in an iranian population. background : epidermal growth factor ( egf ) is one of the important proteins that determine survival of cells. egf binds to its receptor on the cell surface ...
background: the monoclonal antibody, c595, against breast cancer cell line was conjugated with cyclic anhydride gadolinium-diethylenetriaminepenta-acetic acid (gd-cdtpaa) to produce gd-dtpa-c595 and used as specific breast cancer cell line (mcf-7) contrast agents in magnetic resonance imaging (mri). methods: after incubation of breast cancer cell line (mcf-7), with different contrast agents (g...
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