colorectal cancer is an emerging public health problem in indonesia and currently ranks among the three highest cancers. lack of a colonoscopy screening and lifestyle changes might contribute to it. in the last few decades, there is an increasing interest towards the contribution of genetic-environment interaction in colorectal carcinogenesis. some studies have indicated that crc might develop ...

Semaphorin-3F (SEMA3F) is a member of the class III semaphorin family, and is seen as a candidate tumor suppressor gene. The aims of this study were to evaluate the effect of SEMA3F in colorectal cancer (CRC) patients, and to explore the mechanism for that SEMA3F suppresses tumor progression and metastasis. The expression levels of SEMA3F in the colorectal cancer tissues and corresponding non-t...

Colorectal cancer (CRC) has a strong familial component. Candidate genes for colorectal cancer have been identified through mutations in four mismatch repair genes (hMSH2, hMLH1, hPMS1, and hPMS2) and genes that are deleted or mutated in tumors (DCC, APC, and p53). Linkage analysis of candidate loci/regions was performed in 10 kindreds ascertained for common colorectal cancer from the Utah Popu...

it is clear that colorectal cancer (crc) develops through multiple genetic and epigenetic pathways. these pathways may be determined on the basis of three molecular features: (i) mutations in dna mismatch repair genes, leading to a dna microsatellite instability (msi) phenotype, (ii) mutations in apc and other genes that activate wnt pathway, characterized by chromosomal instability (cin) pheno...

background colorectal cancer (crc) is the third most common cancer in iran and its early detection is necessary. this study is based on perception of people in the east of iran toward crc screening.   methods in a cross-sectional study, 1060 randomly selected individuals who referred to razavi hospital of mashhad, iran, between september the 1st, 2012 and february the 28th, 2013 as patients or ...

Colorectal Cancer (CRC) is a global medical challenge. In the KSA, it 1st cancer among males, 3rd females, with death rate of 8.3%. The main purpose CRC screening to detect in early stage where cure can be achieved. So, this study aimed at evaluating public awareness and determining preferred methods conduct concept. A cross-sectional was performed Jeddah, 2019. Data collection done using an on...

background: the prevalence of colorectal cancer (crc) is rapidly increasing in iran. it holds the most prevalent cancer after skin, breast, and gastric cancers among the iranian population. the current study was designed to investigate the effects of leisure time, occupational and household physical activity as well as exercise on the risk of crc in the iranian population. methods: in this popu...

Colorectal cancer (CRC) is a disease classified and based on genetic alteration resulting from interaction of environmental factors, individual cancer susceptibility and accumulated somatic changes of the colorectal epithelium. Advanced knowledge in genetics and epigenetics of colorectal cancer develops a hypothesis that various clinical manifestations of colorectal cancer are caused by differe...

OBJECTIVES The purpose of this paper was to elucidate the potential methylation levels of adjacent normal and cancer tissues by comparing them with normal colorectal tissues, and to describe the correlations between the methylation and clinical parameters in Korean colorectal cancer (CRC) patients. METHODS Hypermethylation profiles of nine genes (RASSF1, APC, p16(INK4a), Twist1, E-cadherin, T...

background: early diagnosis and endoscopic resection of adenomatous polyps is the main approach for screening and prevention of colorectal cancer (crc). we aimed to assess polyp detection rate (pdr) and to characterize demographic, clinical, and pathological features of colorectal polyps in an iranian population. methods: we retrospectively analyzed the data from 5427 colonoscopies performed du...