Influenza B virus (IBV) is a major respiratory pathogen of humans, particularly in the elderly and children, vaccines are most effective way to control it. In previous work, incorporation two mutations (E580G, S660A) along with addition an HA epitope tag PB1 segment B/Brisbane/60/2008 (B/Bris) resulted attenuated strain that was safe as live vaccine. A third attempted mutation (K391E) not alway...

Influenza B viruses circulate globally every year causing respiratory disease with significant clinical and socio-economic impacts. IBV are considered exclusive human pathogens no established animal reservoirs, which suggests concerted effort it may be possible to eradicate this virus from circulation. However, requires a deeper understanding of virology immunology the design vaccines that indu...

avian infectious bronchitis (ib) is a widely distributed poultry disease that has huge economic impact on poultry industry. the continuous emergence of new ibv genotypes and lack of cross protection among different ibv genotypes have been an important challenge. the present study was done to evaluate protection caused by two different serotypes’ vaccines (massachusetts & 793/b) in order to eval...

Infectious bursal disease virus (IBDV) causes a highly immunosuppressive disease in chickens. Currently available, live IBDV vaccines can lead to generation of variant viruses. We have developed an alternative vaccine that will not create variant IBDV. By using the reverse genetics approach, we devised a recombinant Newcastle disease virus (NDV) vector from a commonly used vaccine strain LaSota...

infectious bronchitis virus (ibv) is an acute and contagious viral disease of poultry that affects different systems, including the respiratory tract in particular. ibv causes major economic losses in the poultry industry globally. due to antigenic variation of the causative agent, control of the disease is difficult. to control the disease, many vaccines that belong to different serotypes are ...

Viral pathogens cause devastating economic losses in poultry industries worldwide. The Caribbean region, which boasts some of the highest rates of poultry consumption in the world, is no exception. This review summarizes evidence for the circulation and spread of eight high-priority, economically important poultry viruses across the Caribbean region. Avian influenza virus (AIV), infectious bron...

BACKGROUND Highly-pathogenic avian influenza virus (HPAIV) and Newcastle disease virus (NDV) are the two most important poultry viruses in the world. Natural low-virulence NDV strains have been used as vaccines over the past 70 years with proven track records. We have previously developed a reverse genetics system to produce low-virulent NDV vaccine strain LaSota from cloned cDNA. This system a...