Many pathogenic enveloped viruses, including HIV-1, escape complement-mediated virolysis by incorporating host cell regulators of complement activation into their own viral envelope. The presence of complement regulators including CD59 on the external surface of the viral envelope confers resistance to complement-mediated virolysis, which may explain why human pathogenic viruses such as HIV-1 a...

background: focal segmental glomerulosclerosis (fsgs) is a type of nephrotic syndrome which is diagnosed by renal biopsy. degree of the proteinuria, renal dysfunction, histologic findings and the response to therapy are some factors used for evaluating the prognosis of fsgs. objectives: in the present study, we attempted to discover some protein candidates for disease prognosis related to glome...

An automated method to detect TrypanosomÐ crozi antibodies is described, using complement fixation with an adequate automated equipment. Fifty five serum samples from patients lvhere Trypanosoma cruzi antiþodies were detected by Almeida's technique for complement fixation and by fndirect Immunofluorescence test, were studied by this method. The conclusion is that this automated üechnique can be...

The complement and coagulation systems closely interact with each other. These interactions are believed to contribute to the proinflammatory and prothrombotic environment involved in the development of thrombotic complications in many diseases. Complement MASP-1 (mannan-binding lectin-associated serine protease-1) activates coagulation factors and promotes clot formation. However, this was mai...

It has been shown (Boursnell, Francis & Wormall, 1946) that haemolytic complement is rapidly inactivated by small amounts of sulphur mustard (di-2-chloroethyl sulphide; code no. H) and divinyl sulphone. Since the nitrogen mustards have been widely used during recent years in the treatment of some neoplastic diseases, we decided to study the action, in vitro and in vivo, of a typical nitrogen mu...

A method is described by which complement fixation is detected with an enzyme linked immunosorbant assay (ELISA) technique. The method obviates the need for sensitised sheep red blood cells as an indicator of complement fixation and the titration of complement is not critical. The dose response curve has the advantage of being steep and the test result is read photometrically. As test serum and...