Quantifying the impact of heritable epigenetic variation on complex traits is an emerging challenge in population genetics. Here, we analyze a population of isogenic Arabidopsis lines that segregate experimentally induced DNA methylation changes at hundreds of regions across the genome. We demonstrate that several of these differentially methylated regions (DMRs) act as bona fide epigenetic qua...

Genome sequencing projects have uncovered many novel enzymes and enzyme classes for which knowledge of active site structure and mechanism is limited. To facilitate mechanistic investigations of the numerous enzymes encoded by prokaryotic and eukaryotic genomes, new methods are needed to analyze enzyme function in samples of high biocomplexity. Here, we describe a general strategy for profiling...

Electromagnetic mapping has made possible the routine approach to complex arrhythmia mapping. Originally, it was developed to facilitate accessory pathway location, but it only complicated solitary pathway ablation. Especially, with the introduction of atrial fibrillation ablation, the electromagnetic mapping has become an irreplaceable component of this procedure. Latter, this 3-dimentional ma...

E ver since the initial proposal to use polymorphic DNA markers to map genetic diseases,1 linkage analysis (also called “positional cloning”) has been used successfully to find the gene defects for hundreds of monogenic Mendelian traits.2 Because monogenic diseases can serve as important models for understanding pathogenesis, especially if they point to novel biochemical and physiological pathw...

A procedure to characterize chaotic dynamical systems with concepts of complex networks is pursued, in which a dynamical system is mapped onto a network. The nodes represent the regions of space visited by the system, while edges represent the transitions between these regions. Parameters used to quantify the properties of complex networks, including those related to higher order neighborhoods,...

The remarkable achievements in human genetics over the years have been due to technological advances in gene mapping and in statistical methods that relate genetic variants to disease. Nearly every Mendelian genetic disorder has now been mapped to a specific gene or set of genes, but these discoveries have been limited to high-risk, variant alleles that segregate in rare families. With a workin...

Describing a surface colored model in a proper format is very meaningful to its formation by Color Rapid Prototyping. The proposed format describes the geometry of a solid by a polyhedron consisting of triangular facets, which approaches the geometry of the solid. It also uses a simple method to describe complex surface textures. It uses affine mapping from a rectangular texture image to each f...