Background: Malaria remains an essential tropical protozoal disease, affecting both young and old. It manifests in complicated uncomplicated forms with more grave consequences among Under-five children. Objective: To describe malaria's clinical profile short-term outcomes children a secondary health facility southwest Nigeria. Methods: This was hospital-based cross-sectional study. Five hundred...

Immunoglobulin E has been associated with severe malaria suggesting a regulatory role for interleukin (IL)-4 and/or IgE in the pathogenesis of severe malaria. We have investigated possible associations between polymorphisms in the IL-4 repeat region (intron 3) and promoter regions (IL-4 +33CT and - 590CT) in Ghanaian children with severe malaria. There was a significantly higher frequency of IL...

BACKGROUND Cytokine-mediated endothelial activation pathway is a known mechanism of pathogenesis employed by Plasmodium falciparum to induce severe disease symptoms in human host. Though considered benign, complicated cases of Plasmodium vivax are being reported worldwide and from Pakistan. It has been hypothesized that P.vivax utilizes similar mechanism of pathogenesis, as that of P.falciparum...

INTRODUCTION Malaria causes around 863,000 deaths per year, mostly of them in children under 5 years old. MATERIAL AND METHODS We have reviewed the epidemiological data of malaria cases in a pediatric department in a Hospital in the Community of Madrid, in the period 1996-2011. RESULTS In the period reviewed, 103 cases of malaria were diagnosed in children under 14 years old. Sixty percent ...

INTRODUCTION Malaria is a potentially life-threatening disease, especially when complicated by a septic shock. When patients present in such a critical condition, the currently available literature allows a dilemma to develop as to which the correct treatment strategy is concerning fluid resuscitation. CASE PRESENTATION A 55-year-old Caucasian man was admitted to the intensive care unit with ...

BACKGROUND & OBJECTIVES Morbidity and mortality due to falciparum malaria are increasing in many tropical areas. The situation is further complicated by drug resistant malaria. The present study was undertaken to evaluate the efficacy of arteether on acute chloroquine resistant Plasmodium falciparum malaria in eastern coalfield area of Asansol. METHODS A total of 30 patients with chloroquine ...

Symmetrical peripheral gangrene (SPG) is an extremely rare complication of malaria. It occurs acutely and progresses rapidly to cause irreversible necrosis of tissue following which debridement or amputation is inevitable. We present a case of malaria complicated by SPG. A 54-year old male developed SPG two days after he was diagnosed with severe malaria and treated with intravenous quinine. De...