We present herein a new and efficient four-component synthesis of isoxazol-5(2H)-ones involving ring closing/Knoevenagel condensation/Michael addition sequential reactions.

Currently, there is a trend in nuclear power plants (NPPs) toward introducing digital and computer technologies into main control rooms (MCRs). Safe generation of electric power in NPPs requires reliable performance of cognitive tasks such as fault detection, diagnosis, and response planning. The digitalization of MCRs has dramatically changed the whole operating environment, and the ways opera...

Proteins must fold into their native structures in the crowded cellular environment, to perform their functions. Although such macromolecular crowding has been considered to affect the folding properties of proteins, large-scale experimental data have so far been lacking. Here, we individually translated 142 Escherichia coli cytoplasmic proteins using a reconstituted cell-free translation syste...

Communication in data centers often involves many parallel flows that all share the same performance goal. A useful abstraction, coflow, is proposed to express the communication requirements of prevalent data parallel paradigms. The multiple coflow routing and scheduling problem faces challenges when deriving a good theoretical performance ratio because coexisting coflows will compete for the s...

There are only five mediterranean-climate regions (MCRs) on Earth – the Mediterranean Basin, most of California, central Chile, southern South Africa, and south-central and south-western Australia. They all have cool, or cold, and relatively wet winters alternating with long, hot, and dry summers. Spring and autumn seasons are ephemeral in comparison, and highly variable. During much of the yea...

Reactions of benzoylpyruvate with a mixture of aromatic aldehydes and 5-amino-1,3,4-thiadizole-2-thiol in a 1:1:1 molar ratio, afforded 5-(5-aryl-4-benzoyl-3-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-1,3,4-thiadizole-2-thiols (3a-c). The structure of the resulted products was confirmed by determination of the melting point and spectrophotometric techniques such as IR and 1H-NMR spectroscopy.

Reinforcement Learning (RL) paradigm aims to develop algorithms that allow to train an agent to optimally achieve a goal with minimal feedback information about the desired behavior, which is not precisely specified. Scalar rewards are returned to the agent as response to its actions endorsing or opposing them. RL algorithms have been succesfully applied to robot control design. The extension o...

In document processing, segmentation is done to uniquely identify each foreground connected region of an image by specifying its minimum containing rectangle (MCR). MCR is the rectangle with minimum dimensions that completely encloses a geometric pattern. In this paper, we present a two-step MCR detection algorithm and its parallelization method. The first step determines the boundary of each c...

Simple three-component reactions between dialkyl acetylenedicarboxylate, primary amines and isothiocyanates in the presence of catalytic amount of ZnO nanorods are investigated in water at room temperature which produced thiazole derivatives in good yields.