This paper provides an overview of a statewide survey of child restraint device (CRD) use and misuse in Michigan. The study found that about 75 percent of children under the age of four were in a CRD and that CRD use generally followed the safety belt use patterns of the drivers. The study also found that when a CRD was used, nearly 90 percent of the time an error was made in either how the CRD...

Aberrant gene-environment interactions are implicated in the pathogenesis of congenital renal dysgenesis (CRD), a leading cause of renal failure in infants and children. We have recently developed an animal model of CRD that is caused by gestational salt stress (5% NaCl diet; HS) of bradykinin B2R null mice [B2R(-/-)CRD; El-Dahr SS, Harrison-Bernard LM, Dipp S, Yosipiv IV, and Meleg-Smith S. Ph...

The upgrade of the BESSY II light source in Berlin towards a variable pulse-length storage-ring will lead to complex bunch-filling pattern. This may involve co-existing electron bunches with significant variations their properties. Among many other conditions, it calls for bunch-resolved diagnostics sub-ps time resolution and micrometer spatial resolution. Currently, we are finishing constructi...

AIM The purpose of this study was to evaluate the outcomes of infants diagnosed with retinoblastoma before 6 months of age, including the need for chemoreduction (CRD). In this age group, dosage of CRD was reduced due to its potential for toxicity. METHODS This is a retrospective review from 2000 to 2009 that includes 126 eyes of 72 infants (18 unilateral, 54 bilateral). Systemic CRD was admi...

The human liver and lymph node sinusoidal endothelial cell C-type lectin (hLSECtin), a type II integral membrane protein, containing a Ca(2+)-dependent carbohydrate recognition domain (CRD), has a well-established biological activity, yet its three-dimensional structure is unknown due to low expression yields and aggregation into inclusion bodies. Previous study has demonstrated that the HIV-1 ...

Human pulmonary surfactant protein D (SP-D) is a collagenous C-type lectin with high binding specificity to α-d-glucosyl residues. It is composed of four regions: a short NH2-terminal noncollagen sequence, a collagenous domain, a short linking domain ("neck" region), and a COOH-terminal carbohydrate recognition domain (CRD). Previous studies demonstrated that SP-D is chemotactic for inflammator...

We have analyzed mammary tumors arising in transgenic mice expressing a novel, multifunctional RNA-binding protein. The protein, which we call the c-myc mRNA coding region instability determinant binding protein (CRD-BP), binds to c-myc, insulin-like growth factor II, and beta-actin mRNAs, and to H19 RNA. Depending on the RNA substrate, the CRD-BP affects RNA localization, translation, or stabi...