preparations of platelet concentrates (pcs) that are stored under blood bank conditions and used for transfusion purposes, appear to be enriched in platelet derived-microparticles (pmps) with high coagulant activity that may change platelet efficacy and safety issues. high shear stress could cause shedding of pmps from the platelet plasma membrane, platelet aggregation, and activation of the co...

Objective(s) Theophylline, a xanthenes derivative, is still widely used as an effective bronchodilator in the management of asthmatic patients. It is used both as a prophylactic drug and to prevent acute exacerbations of asthma. The aim of study was to formulate and evaluate effect of the microencapsulation of theophylline loaded nanoparticles on the reduction of burst release. Materials and Me...

We describe droplet microfluidic strategies used to fabricate advanced microparticles that are useful structures for the encapsulation and release of actives; these strategies can be further developed to produce microparticles for advanced drug delivery applications. Microfluidics enables exquisite control in the fabrication of polymer vesicles and thermosensitive microgels from single and high...

Abstract. A mathematical model of enzymes inhibition during microparticles formation has been developed. The model is based on radial substrate diffusion through diffusion layer that surrounds microparticle. The inhibition of enzymes was explained by enzyme adsorption on surface of the microparticles and substrate diffusion limitation through the diffusion layer. The diffusion module is depende...

We propose a recycling strategy for tough polymers based on microparticles. The "microparticle-based" concept allows materials without loss of their properties (‘closed-loop’ recycling).

We are reporting an efficient method for magnetic microparticle based DNA extraction on a segmented flow microfluidic platform [1]. The droplet splitter and the magnetic setup were optimized separately to achieve highest separation efficiency. The novel asymmetric droplet splitter was developed allowing for dynamic control and arbitrary selection of droplet splitting ratios between 50:50 and 95...

Thermal fluctuations significantly affect the behavior of microscale systems rotating in shear flow, such as microvortexes, microbubbles, rotating micromotors, microactuators and other elements of lab-on-a-chip devices. The influence of Brownian torque on the motion of individual magnetic microparticles in a rotating magnetic field is experimentally determined using optical tweezers. Rotational...