The title compound, C(17)H(15)Br(2)NO(6)S(2)·C(2)H(5)OH, is the esterification reaction product of 2-(8,10-dibromo-2,6-dioxo-3,5,5a,11b-tetra-hydro-2H,6H-chromeno[4',3':4,5]thio-pyrano[2,3-d]thia-zol-5a-yl)acetic acid. Cleavage of the lactone ring and formation of eth-oxy-carbonyl and hy-droxy groups from its structural elements were observed. On the other hand, the carb-oxy-methyl group was no...

A new series of anthranilamide derivatives were synthesized and evaluated for their antiproliferative activities against human colon carcinoma cell lines (HCT 116) and human breast adenocarcinoma cell lines (MDA-MB-231) in vitro. The bioassay results indicated that compounds 7a-7d, 11a, and 11b with flexible linkers showed promising antiproliferative activity against both cell lines. Among the ...

The title compound, C(15)H(23)N(2)S(+)·Cl(-)·0.5H(2)O, was prepared from (6aS,11aR,11cS)-2,3,5,6,6a,7,11,11a,11b,11c-deca-hydro-3a,7a-diaza-1H,4H-benzo[de]anthracene-8-one (sophocarpine) and Lawesson's reagent. The thione-substituted ring is in an envelope conformation and the three other six-membered rings are in chair conformations. In the crystal, anions and cations are linked by N-H⋯Cl and ...

Glycyrrhiza species (G. uralensis, G. glabra, and G. inflata) has been reported to possess various pharmacological activities such as anti-inflammation, inhibition of prostaglandin E2 (PGE2) production in rat macrophages, 2) antiallergic, antiviral action, and interferon-g-induction. In Japan, a glycyrrhizin preparation, Stronger-Neo Minophagen C (SNMC), has been used extensively for more than ...

We report the direct measurement of orbital period decay in the double neutron star pulsar system PSR B2127+11C in the globular cluster M15 at the rate of (−3.95± 0.13)× 10, consistent with the prediction of general relativity at the ∼ 3% level. We find the pulsar mass to be mp = (1.358 ± 0.010)M⊙ and the companion mass mc = (1.354 ± 0.010)M⊙. We also report long-term pulse timing results for t...

The 1,2-hydroboration of various alkyn-1-yl(chloro)silanes (3 – 7), derived from 1-hexyne (a) and ethynylbenzene (b), using 9-borabicyclo[3.3.1]nonane, 9-BBN, affords selectively alkene derivatives in which the dialkylboryl and chlorosilyl groups are in geminal positions at the C=C bond. The molecular structure of (Z)-α-(9-borabicyclo[3.3.1]non-9-yl)-α-dichloro(phenyl)silyl-styrene (11b) was de...