BACKGROUND Computer-aided drug design is still a state-of-the-art process in medicinal chemistry, and the main topics in this field have been extensively studied and well reviewed. These topics include compound databases, ligand-binding pocket prediction, protein-compound docking, virtual screening, target/off-target prediction, physical property prediction, molecular simulation and pharmacokin...

background: the purpose of this study was to evaluate the influence of three different luting protocols on shear bond strength of computer aided design/computer aided manufacturing (cad/cam) resin nanoceramic (rnc) material to dentin. materials and methods: in this in vitro study, 30 disks were milled from rnc blocks (lava ultimate/3m espe) with cad/cam technology. the disks were subsequently c...

The drug development and discovery process are challenging, take 15 to 20 years, require approximately 1.5-2 billion dollars, from the critical selection of target molecule post-clinical market application. Several computational design methods identify optimize biologically lead compounds. Given complexity cost in recent computer-assisted (CADD) has spread over a broad spectrum. CADD support mo...

recently, as the result of the development in modern imaging, computerized three dimensional data processing and advanced engineering techniques, an prosthesis that match the skeletal anatomy can be accurately designed from computer aided design (cad) technique and the physical model of prosthesis or skull replica can be produced through rapid prototyping (rp), rapid tooling (rt), and computer ...

operator's role in industrial control centers takes place in time, which is one of the most important determinants of whether an expected action is going to be successful or not. in certain situations, due to the complex nature of the work, the existing interfaces and already prepared procedures do not meet the dynamic requirements of operator's cognitive demands, making the control tasks unnec...