Abstract Studies in recent decades demonstrate the significant effect of stress configuration (e.g., vertical and lateral confinement) on shear strength or, this study, cone penetration test (CPT) results. Addition a surcharge over ground changes condition, consequently, CPT tip resistance. In results different CPTs conducted before after backfilling with various thicknesses land development pr...

The formation of a growth cone at the tip of a severed axon is a key step in its successful regeneration. This process involves major structural and functional alterations in the formerly differentiated axonal segment. Here we examined the hypothesis that the large, localized, and transient elevation in the free intracellular calcium concentration ([Ca2+]i) that follows axotomy provides a signa...

Directional variability of spatial correlation is observed in natural soils due to their depositional characteristics and it influences the response of structures founded on these deposits. Nonetheless, the results presented in most of the available literature are based on the assumption of either isotropic spatial correlation or perfect spatial correlation of soil properties in horizontal and ...

The complex process of axon guidance is largely driven by the growth cone, which is the dynamic motile structure at the tip of the growing axon. During axon outgrowth, the growth cone must integrate multiple sources of guidance cue information to modulate its cytoskeleton in order to propel the growth cone forward and accurately navigate to find its specific targets(1). How this integration occ...

the produced electric and magnetic fields due to lightning strikes to mountainous ground are determined in this paper. for the sake of simplicity a cone-shaped ground with finite conductivity is assumed to represent a natural nonflat ground. by this assumption, we deal with an axillary symmetrical structure so we use the cylindrical 2d-fdtd to save the simulation memory and time, dramatically. ...

During development, axons elongate vigorously, carefully controlling their speed, to connect with their targets. In general, rapid axon growth is correlated with active growth cones driven by dynamic actin filaments. For example, when the actin-driven tip is collapsed by repulsive guidance molecules, axon growth is severely impaired. In this study, we report that axon growth can be suppressed, ...

The rapid evolution of RNA-encoded viruses such as HIV presents a major barrier to infectious disease control using conventional pharmaceuticals and vaccines. Previously, it was proposed that defective interfering particles could be developed to indefinitely control the HIV/AIDS pandemic; in individual patients, these engineered molecular parasites were further predicted to be refractory to HIV...

The classification of soils into categories with a similar range properties is fundamental geotechnical engineering procedure. At present, this based on various types cost- and time-intensive laboratory and/or in situ tests. These soil investigations are essential for each individual construction site have to be performed prior the design project. Since Machine Learning could play key role redu...

An apparatus that integrates solid-state nanopore ionic current measurement with a scanning-probe microscope is developed. When a micrometer-scale scanning-probe tip is near a voltage-biased nanometer-scale pore (10–100 nm), the tip partially blocks the flow of ions to the pore and increases the pore access resistance. The apparatus records the current blockage caused by the probe tip and the l...

OBJECTIVE To determine whether and by what mechanism systemic delivery of curcumin-containing liposomes improves insulin resistance in the leptin deficient (ob/ob) mouse model of insulin resistance. RESEARCH DESIGN AND METHODS Insulin resistant ob/ob mice with steatosis were injected intraperitoneally with liposome nanoparticles, entrapping the nuclear factor-κB (NF-κB) inhibitor curcumin (cu...