Pyridine appended structural isomers showed a planar or propeller conformation dependent molecular self-assembly, fluorescent polymorphs, stimuli-responsive fluorescence switching and halochromism.

familial hypercholesterolemia (fh) is an autosomal co-dominant disorder of lipid metabolism, caused by mutations in ldl receptor gene. the penetrance of fh is almost 100%, meaning that half of the offspring of affected parents born with disease. the patients are at risk of premature coronary heart disease (chd). there is no report about the molecular basis of fh in iran. identification of mutat...

The structure solution of the δ-polymorph indomethacin was obtained using three-dimensional electron diffraction. This form shows a significantly enhanced dissolution rate compared with more common and better studied α- γ-polymorphs, indicating biopharmaceutical properties for medicinal applications. solved in non-centrosymmetric space group P21 comprises two molecules asymmetric unit. Packing ...

2014 We study the conformation of randomly branched, monodispersed polymers both in dilute and concentrated solutions in their reaction bath. We first extend the Zimm-Stockmayer mean field theory to such properties as elasticity and concentration correlations. We then take this mean field theory as a basis for a Flory approach. In a dilute solution, we recover previous results by Isaacson and L...

Protein conformation problem, one of the hard and important problems, is to identify conformation rules which transform sequences to their tertiary structures, called conformations. Our aim of this work is to give a concrete theoretical foundation for graph-theoretic approach for the protein conformation problem in the framework of a probabilistic learning model. We propose the conformation pro...

T-Taxol is a proposal for the bioactive conformation of paclitaxel (PTX) derived from fitting ligand conformations to the electron crystallographic (EC) density. Although confirmed by a number of studies, some structural ambiguities based on the interpretation of two solid-state REDOR (13)C-(19)F distances in a fluorinated PTX derivative remain. An evaluation of the static and dynamic propertie...

Chromatin conformation capture (3C) and related techniques have become well-established methods to examine which distal DNA sequences are spatially located close to a locus of interest. Hi-C is a new addition to the growing set of 3C-based techniques that has extended the approach to a genome-wide analysis of nuclear chromatin using high-throughput DNA sequencing to generate global interaction ...

The purpose of this paper is to offer demonstrations of 'illusory volumes' in the spirit of the illusory flat surfaces described by Kanizsa. These demonstrations of illusory volumes exploit a new cue to the recovery of surface curvature from ambiguous images: conformation. In assuming conformation, the visual system assumes that the surface of a volume conforms to the curvature of its neighbori...