CASE SUMMARY We describe the case of a 1-year-old male Persian cat diagnosed with congenital hepatic fibrosis (CHF) associated with renal polycystic disease and, for the first time, we have shown that there was no C >A mutation in exon 29 of PKD1 (polycystic kidney disease 1). The cat presented with a history of chronic weight loss, anorexia, vomiting, depression and lethargy, with profuse sali...

liver fibrosis is a potentially reversible response to hepatic insults, triggered by different chronic diseases most importantly viral hepatitis, alcoholic, and non-alcoholic fatty liver disease. in the course of the chronic liver disease, hepatic fibrogenesis may develop, which is attributed to various types of cells, molecules, and pathways. activated hepatic stellate cell (hsc), the primary ...

Background: Hepatic steatosis is commonly observed in patients with chronic hepatitis C (CHC). Many studies indicate a relationship between steatosis and fibrosis progression. The aim of this study was to analyze the prevalence of hepatic steatosis and related factors in Iranian CHC patients.   Methods: One hundred and fifteen consecutive patients with CHC were enrolled which were treat...

conclusions fib-4 confirmed the best value for diagnosis of significant fibrosis. apri had a sub-optimal diagnosis accuracy for significant fibrosis. lsm showed the most balance diagnosis value for cirrhosis with the highest sensitivity and moderate specificity. patients and methods a total of 544 patients with chb were assessed for fibrosis stage by four noninvasive tests containing liver stif...

Aim Patients who undergo the Fontan procedure for complex congenital heart disease are prone to liver cirrhosis. Liver stiffness (LS) reflects fibrosis stage in patients with chronic viral hepatitis; however, its accuracy predicting is controversial. We aimed clarify correlation between LS and patients. Methods Fifty-eight were prospectively measured transient elastography. undertook biopsy, ca...

Rall J E, Odel H M. Congenital polycystic disease of the kidney: review of the literature and data on 207 cases. AmJ Med Sci 1949; 218: 399-407. 2 Bradford W D, Bradford J W, Porter F S, Sidbury J B, Jr. Cystic disease of liver and kidney with portal hypertension: a cause of sudden unexpected hematemesis. Clin Pediatr (Phila) 1968; 7: 299-306. 3 Parker R G F. Fibrosis of the liver as a congenit...

Introduction There are several congenital cystic conditions affecting the liver and bile ducts. The first group includes the intrahepatic cysts, which may be solitary or multiple, and their precursors, the von Meyenburg complexes. These are microscopic areas of duct ectasia which may enlarge gradually to form macroscopic cysts. The second group includes those lesions affecting the biliary drain...

Congenital hepatic fibrosis (CHF) is a rare, autosomal recessive disorder, clinically characterized by hepatic fibrosis and portal hypertension. CHF results from ductal plate malformation (DPM) of the intrahepatic bile ducts. Four clinical forms can be observed: portal hypertensive, cholangitic, mixed and latent. CHF is one of the "fibropolycystic diseases" which also include several conditions...