Water-specific aquaporins (AQP), such as the prototypical mammalian AQP1, stringently exclude the passage of solutes, ions, and even protons. Supposedly, this is accomplished by two conserved regions within the pore, a pair of canonical asparagine-proline-alanine (NPA) motifs, the central constriction, and an aromatic/arginine (ar/R) constriction, the outer constriction. Here, we analyzed the f...

Background—a-Adrenergic activation in vivo causes constriction of coronary arterioles, but, paradoxically, in vitro these microvessels do not contract to this stimulus. We hypothesized that cardiac myocytes have a requisite role in a1-adrenergic coronary arteriolar constriction through the release of myocyte-derived contractile factor(s). Methods and Results—Administration of the a1-adrenergic ...

BACKGROUND Alpha-adrenergic activation in vivo causes constriction of coronary arterioles, but, paradoxically, in vitro these microvessels do not contract to this stimulus. We hypothesized that cardiac myocytes have a requisite role in alpha1-adrenergic coronary arteriolar constriction through the release of myocyte-derived contractile factor(s). METHODS AND RESULTS Administration of the alph...

Recent work shows that Wnt signaling directly regulates the apical constriction that drives gastrulation movements in Caenorhabditis elegans, and also promotes invagination in sea urchins, providing a novel and possibly conserved mode of developmental regulation.

The airflow in the modeled glottal constriction was simulated by the solutions of the Navier-Stokes equations for laminar flow, and the corresponding Reynolds equations for turbulent flow in generalized, nonorthogonal coordinates using a numerical method. A two-dimensional model of laryngeal flow is considered and aerodynamic properties are calculated for both laminar and turbulent steady flows...

A 25-day-old male neonate was received in our outpatient department with constriction ring of right leg with bluish discoloration and swelling of foot and acro-syndactly of both hands. The constriction ring was threatening to the limb that already had lost digits as an in-utero event. Multiple Z-Plasties of half circumference of leg was done with release of constriction band. Wound was stitched...

We present transport measurements of a nondegenerate two-dimensional electron system on the surface of liquid helium at a point constriction. The constriction is formed in a microchannel by a split gate beneath the helium surface. The electrostatic energy of the electron system, which depends in part on the electron density, determines the split-gate voltage threshold of current flow through th...