Array-based Discovery of Aptamer Pairs Report Title Affinity reagent pairs that recognize distinct epitopes on a target protein can greatly improve the sensitivity and specificity of molecular detection. Importantly, such pairs can be conjugated to generate reagents that achieve twosite “bidentate” target recognition, with affinities greatly exceeding either monovalent component. DNA aptamers a...

Most applications running on the Java Virtual Machine (JVM) make extensive use of dynamic object-oriented programming features such as inheritance, polymorphism, and encapsulation. This makes them very hard or even impossible to analyze statically, defeating most of the automatic parallelization research done so far for traditional computeheavy scientific applications. In this paper, we propose...

Obtaining solutions of the Eliassen balanced vortex model requires solving an invertibility relation, which is a nonlinear elliptic problem of the MongeAmpere type. Multigrid techniques for this problem are investigated. An adaptive algorithm which combines the full multigrid method with continuation in a parameter related to the strength of the forcing is developed. Numerical results demonstra...

In this note we study the mathematical theory of one particular algorithm for nonholonomic point-to-point path nding. The algorithm considered here is a \continuation" or \deformation" method, in which one starts with an admissible trajectory that goes from the desired initial point p to some point q0, and then tries to construct a one-parameter family of trajectories, whose terminal points qs ...

We consider the problem of calculating the electronic absorption spectrum of a chromophore with intramolecular degrees of freedom coupled to a condensed phase environment. We approach this calculation in the framework of the imaginary-time path integral Monte Carlo techniques, and focus on the problem of the analytic continuation of the imaginary-time data to the real-time axis. Two alternative...

OBJECTIVE To examine the effect of age on continuation rates of reversible contraceptive methods among females aged 14-19 years and women aged 20-25 years compared with women older than 25 years of age. METHODS We analyzed data from 7,472 participants enrolled in the Contraceptive CHOICE Project, a prospective cohort study of women offered no-cost contraception. Our primary objective was to c...

The continuation method is a popular approach in non-convex optimization and computer vision. The main idea is to start from a simple function that can be minimized efficiently, and gradually transform it to the more complicated original objective function. The solution of the simpler problem is used as the starting point to solve the original problem. We show a continuation method for discrete...

background: when family planning programmes offer a wide variety of contraceptives, contraceptive prevalence would be higher overall. objective: to determine the acceptability of cyclofem© and to evaluate its side effects and continuation rate in iran. materials and methods: an introductory study of cyclofem© was conducted in seven districts of kerman province, the largest province of iran, in ...

Three-dimensional (3D) limit analysis of stability of slopes is presented. Such analyses are not common because of the difficulties in constructing three-dimensional mechanisms of failure in frictional soils. While examples of 3D translational failure patterns are known, no admissible rotational mechanisms for frictional soils have been described in the literature. A class of admissible rotatio...

Previous studies demonstrated that brain signals encode information about specific features of simple auditory stimuli or of general aspects of natural auditory stimuli. How brain signals represent the time course of specific features in natural auditory stimuli is not well understood. In this study, we show in eight human subjects that signals recorded from the surface of the brain (electrocor...