A young woman with no history of diabetes tried to commit suicide by injecting 2800 units of subcutaneous NPH insulin. She was transferred to Loghman Hospital within 12 hours. The main clinical symptom was continuous seizure activity which was resistant to all forms of routine drug therapy. The patient was treated with intravenous hypertonic glucose (50%) followed by continuous glucose (10...

Sixty minutes' intravenous glucose infusion tests were carried out in normal subjects, borderline cases, and diabetics which were diagnosed by 50 g oral glucose tolerance test . Infusion was performed at the rate of 5 mg/kg/min . or 15 mg/kg/min. using 5% or 10% glucose. The difference in the insulin responses among thesegroups was rather marked in the case of 15 mg/kg/min. infusion of 10% gluc...

Compared with intermittent infusion, continuous infusion of vancomycin is cheaper and logistically more convenient, achieves target concentrations faster, results in less variability in serum vancomycin concentrations, requires less therapeutic drug monitoring and causes less nephrotoxicity. Given that critically ill patients may develop very large volumes of distribution as well as supranormal...

We have compared tactile assessment of the train-of-four (TOF) count and TOF ratio by nursing staff, with measurements made by a new acceleromyographic monitor, the TOF-Watch. We assessed neuromuscular block in 30 sedated intensive care patients receiving a continuous infusion of atracurium. Five nurses made a tactile assessment of neuromuscular block in each patient within a 5-min period. Each...

The plasma clearance rates of factors IX and VIII were determined in patients with hemophilia A and B who had received factor replacement by prolonged, continuous infusion of factor concentrates. The clearance rates were calculated by dividing the factor infusion rates by the steady-state plasma factor activities corrected for base-line factor activities. The mean factor IX clearance rate in ei...

Bactericidal activity of ceftazidime is determined by the time that concentrations in tissue and serum are above the MIC for the pathogens during the dosing interval. Thus, the most effective mode of administration of ceftazidime is continuous infusion. However, this agent is light sensitive which may result in instability when administered by this method without protection from light. Until no...

1. By a method of hepatic venous catheterization previously described, comparative data have been obtained concerning the removal of pneumococci from the splanchnic circulating blood of the intact rabbit in bacteriemias secondary to a dermal infection and in bacteriemias induced by a continuous infusion of organisms into the blood stream. The average splanchnic removal in secondary pneumococcal...