This report introduces the overview and main mechanism of hyperthermia and summarizes the clinical application of hyperthermia in integrative natural therapies of cancer. According to the clinical experiences of the author, through statistical analysis, this report explains the orientation, application, and efficacy evaluation of hyperthermia in integrative natural therapies of cancer, as well ...

1. The pharmacology of the acute hyperthermia that follows 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') administration to rats has been investigated. 2. MDMA (12.5 mg kg(-1) i.p.) produced acute hyperthermia (measured rectally). The tail skin temperature did not increase, suggesting that MDMA may impair heat dissipation. 3. Pretreatment with the 5-HT(1/2) antagonist methysergide (10 mg k...

A novel therapy is demonstrated utilizing magnetic nanoparticles for the dual purpose of delivering microRNA and inducing magnetic hyperthermia. In particular, the combination of lethal-7a microRNA (let-7a), which targets a number of the survival pathways that typically limit the effectiveness of hyperthermia, with magnetic hyperthermia greatly enhances apoptosis in brain cancer cells.

Background Mild hyperthermia (41.5-44°C) has been shown to enhance the effect of radiotherapy and chemotherapy. However, currently available heating methods are often inefficient in inducing conformal hyperthermia for deep seated targets. Here, the software of Philips Sonalleve V2 MR-HIFU system was modified to enable performing a long duration large volume hyperthermia sonication in in-vivo po...

The review by Rampersaud and colleagues provides an excellent summary of the scientific rationale for using hyperthermia to treat cancer and of the current status of combinations of hyperthermia and chemotherapy or radiotherapy. In view of the demonstrated efficacy of the combination of intravescial hyperthermia and mitomycin C (MMC) therapy in preventing the progression and recurrence of non–m...

Magnetic nanoparticles offer some attractive possibilities in biomedicine because it has the special physical properties. Magnetic hyperthermia using magnetic nanoparticles requires that the magnetic particles have not only high heating ability in low magnetic field but also to be non-toxic for biomedical use. Although the reports of bulk magnetic materials or Fe3O4 nanoparticles have known for...

The aim of this study was to characterize a novel animal model hyperthermia-induced febrile seizure and to investigate the impacts of repetitive febrile seizures on spatial learning and memory performances in immature rats. Methods. Rats were subjected to hyperthermia exposure one, two, or three times in 10-day intervals during 30 min in a water bath warmed at 45-50°C and their behaviour was mo...

We report a case of malignant hyperthermialike syndrome in a living-donor liver transplant recipient with no familial history of malignant hyperthermia or exposure to known triggering drugs. The patient showed many features of a typical malignant hyperthermia episode, and The Clinical Grading Scale defined this case as almost certain to be an episode of malignant hyperthermia (rank 5). However,...

A 42-year-old man with neck squamous cell carcinoma underwent awake fiberoptic intubation and tumor resection under general anesthesia. He developed malignant hyperthermia several hours into the surgical procedure. This case highlights hyperthermia’s (MH) variable time course, pathognomonic signs, need for rapid diagnosis treatment. Early recognition treatment led to resolution of MH. Ongoing d...

BACKGROUND The optimum treatment for high-risk soft-tissue sarcoma (STS) in adults is unclear. Regional hyperthermia concentrates the action of chemotherapy within the heated tumour region. Phase 2 studies have shown that chemotherapy with regional hyperthermia improves local control compared with chemotherapy alone. We designed a parallel-group randomised controlled trial to assess the safety ...