This review offers insight into disease management of psoriasis and pharmaceutical approach for the effective drug delivery for the treatment of this disease. Several treatment regimens has been tried for psoriasis but rate of success is always limited as for as conventional system is concerned. This review deals in details about topical drug delivery in general and its challenges in designing ...

Conventional drug delivery systems have little control over their drug release and almost no control over the effective concentration at the target site. The major problem associated with conventional drug delivery system is unpredictable plasma concentrations. Osmotic devices are the most promising strategy based systems for controlled drug delivery. They are the most reliable controlled drug ...

Intervention Women were allocated to intensive (n=85) or conventional (n=91) treatment. Intensive treatment consisted of provision of information and conversation regarding previous obstetric experiences, feelings, and misconceptions; routine obstetric check ups; and cognitive treatment. A midwife appointment and visits to the obstetric ward were recommended for information about pain relief an...

We reported an innovative, targeted chemoimmuno drug-delivery system. Although chemoimmunotherapy, as an alternative to or in combination with conventional therapeutic systems, has been in the forefront of recent oncological research, as presently configured, such systems face several major obstacles for efficient clinical application. Here, we establish a novel nano-platform for effective chem...

The last step of a successful pregnancy is the safe delivery of the fetus. An important question is if the delivery should vaginal or operative. In addition to the use of conventional antenatal ultrasound, the use of intrapartum ultrasound to evaluate fetal head station, position, cervical ripening, and placental separation is promising. This review evaluates and summarizes the usefulness of in...

Faced with surging drug development costs and fierce generic competition, pharmaceutical companies are under increasing pressure to find ways to increase and prolong the profitability of both existing and new products. In addition, many of the advanced molecules being developed by biotechnology companies require more efficient delivery than that offered by conventional delivery routes and syste...

Microneedles were first conceptualized for drug delivery many decades ago, overcoming the shortages and preserving the advantages of hypodermic needle and conventional transdermal drug-delivery systems to some extent. Dissolving and biodegradable microneedle technologies have been used for transdermal sustained deliveries of different drugs and vaccines. This review describes microneedle geomet...

To investigate the influence of vascular normalization on solid tumor blood perfusion and drug delivery, we used the generated blood vessel network for simulations. Considering the hemodynamic parameters changing after antiangiogenic therapies, the results show that the interstitial fluid pressure IFP in tumor tissue domain decreases while the pressure gradient increases during the normalizatio...

background: the increasing number of cesarean section is a great concern in many countries. in iran cesarean section rate has been steadily rising from 35% in 2000 to 40% in 2005. preferences for cesarean are often associated with some factors. objective: to investigate factors associated with preference for cesarean delivery, with special emphasis on pregnant women’s preferences in first pregn...

Background Needle-free, painless and localized drug delivery has been a coveted technology in the area of biomedical research. We present an innovative way of trans-dermal vaccine delivery using a miniature detonation-driven shock tube device. This device utilizes~2.5 bar of in situ generated oxyhydrogen mixture to produce a strong shockwave that accelerates liquid jets to velocities of about 9...