Background: Hepatitis C virus (HCV) is a main public health problem causing chronic liver infection and subsequently liver cirrhosis and lethal hepatocellular carcinoma (HCC). Vaccination based on HCV capsid proteins has attracted a special interest for prevention of viral infections. The core protein is a basic and evolutionary most conserved protein, which regulates the cellular processes rel...

Abstract A separable covariance model can describe the among-row and among-column correlations of a random matrix permits likelihood-based inference with very small sample size. However, if assumption separability is not met, data analysis may misrepresent important dependence patterns in data. As compromise between unstructured estimation, we decompose into component complementary ‘core’ matri...

In the data preparation phase of a data mining task the raw, fine granulated data has to be transformed according to analytical aims into a more compact form in order to represent data at a higher abstraction level suitable for machine processing and human understanding as well. Vast datasets require sophisticated, out-of-core methods, which are prepared to handle these datasets using external ...

This paper describes techniques for implementing irregular out-of-core codes on distributed memory machines. These codes involve data arrays and other data structures that are too large to t in main memory; so data needs to be stored on disks and fetched during the execution of the program. The eecient use of disk storage is a critical factor that determines the performance of these application...