BACKGROUND Patients treated by cardiac transplantation who survive beyond one year are at significant risk from fatal coronary artery disease. The development of coronary artery calcification in these patients is discussed and methods available to detect it are reviewed. OBJECTIVES To assess the clinical importance of coronary artery calcium in heart transplant recipients. METHODS In a coho...

BACKGROUND Adequate calcium intake is known to protect the skeleton. However, studies that have reported adverse effects of calcium supplementation on vascular events have raised widespread concern. OBJECTIVE We assessed the association between calcium intake (from diet and supplements) and coronary artery calcification, which is a measure of atherosclerosis that predicts risk of ischemic hea...

Calcification of the coronary arteries plays a key role in the pathophysiology of atherosclerosis. Coronary calcification is an active process culminating in extracellular matrix deposition of calcium by osteoblast-like cells that has some resemblance to bone formation [1]. Subintimal coronary calcification is almost exclusively associated with the presence of coronary atherosclerosis and is co...

Coronary artery calcification quantification (scoring) has been done with electron beam CT (EBCT), but is now being done with spiral or helical CT. Many radiologists and cardiologists who do not have EBCT but do have access to spiral CT will now be able to do coronary artery calcification scoring, and will now need to know the spiral CT appearance of the coronary artery anatomy. This pictorial ...

OBJECTIVE To assess the effects of famine exposure during childhood on coronary calcium deposition and, secondarily, on cardiac valve and aortic calcifications. DESIGN Retrospective cohort. SETTING Community. PATIENTS 286 postmenopausal women with individual measurements of famine exposure during childhood in the Netherlands during World War II. INTERVENTION/EXPOSURE Famine exposure dur...

BACKGROUND Recent genome-wide association studies have identified 49 single nucleotide polymorphisms associated with clinical coronary artery disease. The mechanism by which these loci influence risk remains largely unclear. METHODS AND RESULTS We examined the association between a genetic risk score composed of high-risk alleles at the 49 single nucleotide polymorphisms and the degree of sub...

Calcification is a very common phenomenon in the coronary arteries, which part of atherosclerotic process, and degree calcification can predict clinical outcomes patients at high risk events. Both patterns its distribution are prognostic importance, but relationship artery with plaque instability extremely complex not fully understood. This article devoted to study markers their influence on de...

BACKGROUND Cardiovascular disease (CVD) is the main cause of mortality in patients with chronic kidney disease (CKD). The pathophysiology of coronary artery disease in CKD is multifactorial including, in addition to traditional risk factors (hypertension, hyperlipidemia, diabetes mellitus), parameters related to uremia. METHODS The study consisted of measuring coronary artery calcification (C...