The three mammalian nitric-oxide synthases produce NO from arginine in a reaction requiring 3 electrons per NO, which are supplied to the catalytic center from NADPH through reductase domains incorporating FAD and FMN cofactors. The isoforms share a common reaction mechanism and requirements for reducing equivalents but differ in regulation; the endothelial and neuronal isoforms are controlled ...

Abstract In this article we prove the global existence of weak solutions for a diffuse interface model in bounded domain (both 2D and 3D) involving incompressible magnetic fluids with unmatched densities. The couples Navier–Stokes equations, gradient flow magnetization vector Cahn–Hilliard dynamics describing partial mixing two fluids. density mixture depends on an order parameter modelling (sp...

BACKGROUND There is increasing recognition that perinatal common mental disorders (PCMDs) are prevalent in women in low and lower-middle income countries and emerging evidence that PCMDs and alcohol abuse occur in men in these settings. Domestic violence is associated with PCMDs in both women and men. The aim of this study was to examine the relationships among PCMDs, alcohol abuse and domestic...

We provide a simple, but physical analysis for cell irreversibility and apoptosis in response to an ultrashort (nanosecond), high-intensity electric pulse. Our approach is based on an energy landscape model for determining the temporal evolution of the configurational probability function p(q). The primary focus is on obtaining qualitative predictions of a pulse width dependence to apoptotic ce...

We analyze the stoichiometry, energetics, and reaction concentration dependence of the reductive tricarboxylic acid (rTCA) cycle as a universal and possibly primordial metabolic core. The rTCA reaction sequence is a network-autocatalytic cycle along the relaxation pathway for redox couples in nonequilibrium reducing environments, which provides starting organic compounds for the synthesis of al...

Magnetic field induced switching of the antiferromagnetic order parameter in thin films of magnetoelectric chromia" (2015). A Landau-theoretical approach is utilized to model the magnetic field induced reversal of the antiferromagnetic order parameter in thin films of magnetoelectric antiferromagnets. A key ingredient of this peculiar switching phenomenon is the presence of a robust spin polari...

conclusions the results of this study in terms of personality disorders and types of used drugs were in accordance with the previous studies results. it is necessary to design appropriate treatment plans for medical treatment of those with personality disorders. results there was a significant correlation between stimulant use and histrionic personality disorder (p < 0.001) and antisocial and n...

The concept of the “Kondo box” describes a single spin, antiferromagnetically coupled to a quantum dot with a finite level spacing. Here, a Kondo box is formed in a carbon nanotube interacting with a localized electron. We investigate the spins of its first few eigenstates and compare them to a recent theory. In an “open” Kondo-box, strongly coupled to the leads, we observe a nonmonotonic tempe...

ATP synthase couples proton flow to ATP synthesis, but is leaky to protons at very low nucleotide concentration. Based on the bi-site mechanism, we simulated the proton conduction from proton slip to "coupled" proton flow in ATP synthase using the Monte Carlo method. Good agreement is obtained between the simulated and available experimental results. Our model provides deeper insight into the n...