Three healthy young men participating in phase 1 clinical vaccine trials had unexplained increases in their serum transaminase levels. Retrospective analysis indicated that these volunteers had participated in strenuous physical training 2-5 days prior to the noted elevations. The pattern of serum enzyme elevations, initially thought to be consistent with hepatic injury, were associated with pa...

Extracts of embryonic mouse tissues (skeletal, cardiac and smooth muscle, and brain) were analysed by Cellogel electrophoresis for their isoenzymic distributions of three enzymes, creatine phosphokinase, aldolase and phosphoglycerate mutase. Embryonic tissues from the 12th day to the end of gestation were examined for isoenzyme transitions, and it was found that the adult forms of these enzymes...

C rush injury leading to rhabdomyolysis is one of the dreaded complications of natural catastrophes such as earthquakes. Rhabdomyolysis is a syndrome characterized by muscle necrosis and the release of intracellular muscle constituents, namely creatine phosphokinase, myoglobin, and various electrolytes into the circulation. Precipitation of myoglobin in the renal tubules with secondary obstruct...

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