background: vast variety of intermediate factors including cell cycle regulators, growth factors, transcription factors, and signaling pathways are involved in hematopoietic stem cell (hsc) commitment and differentiation into distinct lineages. vhl, ecad, and runx3 are among these. epigenetics is currently introduced as a potential mechanism to control the gene regulation. the aim of this study...

background:class ii transactivator (ciita) is a dominanttranscriptional element, controlling numerous genes in theimmune system. ciita is expressed in a constitutive pattern inantigen presenting cells although its expression can occur inother cell types. since the revelation of ciita, there have beenconsiderable advances toward understanding its role as anactivator of mhc ii genes in humans and...

lentinan a polysaccharide from medicinal mushroom i.e lentinus, has been known to have anticancer properties. telomerase activity is not observed in normal healthy cells, whereas in cancerous cells telomerase expression is high. telomerase represents a promising cancer therapeutic target. we investigated the inhibitory effect of lentinan on telomerase reverse transcriptase gene (htert) which is...

The synthesis of estradiol by the granulosa cells is a prominent event in ovarian physiology and depends on the expression of P450(AROM). FSH induces the expression of P450(AROM) in granulosa cells as a result of the presence in the ovarian promoter of a CRE (cAMP response element)-like sequence (CLS). In rodents, LH downregulates aromatase expression during luteinization by an as yet undescrib...

background: the availability of testis specific genes will be of help in choosing the most promising biomarkers for the detection of testicular sperm retrieval in patients with non-obstructive azoospermia (noa). testis specific chromodomain protein y 1 (cdy1) is a histone acetyltransferase which concentrates in the round spermatid nucleus, where histone hyperacetylation occurs and causes the re...

ICER is a member of the CREM family of basic leucine zipper transcription factors that acts as a dominant negative regulator of gene transcription. Four different isoforms of ICER (I, Igamma, II and IIgamma) are transcribed from the P2 promoter of the Crem gene. We previously found that each of the ICER isoforms is induced by parathyroid hormone in osteoblasts. The goal of the present study was...

introduction: hepatitis c virus (hcv) is the major cause of acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma worldwide. because of increasing number of infected patients throughout the world, various studies are concentrated on development of high quality diagnostic tests and genotyping in various regions of the world. methods: in this study, we used rt-pcr to isolate and a...

the aims of this study were to compare the promoter sequence of the mannose-binding lectin (cmbl) gene in iranian native and commercial chicken strains; as well as to compare the cmbl gene expression in crossbred and inbred chickens. in total 79 native (western azerbaijan native fowls, wanf) and 49 commercial (arian commercial strain, acs) birds were reared as parents under same management prac...

introduction: endurance training has significant effects on the renewal of heart tissue, including myosin heavy chain (mhc) proteins. on the other side, purine-rich element-binding protein β (purb) decreases the &alphamhc; gene expression. the aim of this study was to determine the impact of exercise endurance training on purb gene expression in the heart of wistar rats. methods: fourteen rats ...

brucellosis, caused by brucella spp., is an important zoonotic disease that causes abortion and infertility in cattle and undulant fever in humans. various studies have examined cell-free native and recombinant proteins as candidate protective antigens in animal models. among brucella immunogenes, antigen based on ribosomal preparation has been widely investigated. in this study, the immunogeni...