BACKGROUND AND AIMS Glucagon-like peptide 2 (GLP-2) has been shown to improve intestinal absorption in short bowel syndrome (SBS) patients in a short-term study. This study describes safety, compliance, and changes in quality of life in 11 SBS patients at baseline, week 13, 26, and 52 during two years of subcutaneous GLP-2 treatment, 400 microgram TID, intermitted by an 8-week washout period. ...

We welcome the interest shown by colleagues in Rome about the Ulcerative Colitis Endoscopic Index of Severity [UCEIS]1,2 and their suggestion that it might be enhanced by segmental scoring at full colonoscopy. When the score was being developed,3 the international working group felt that a major goal was for the score to be simple, not to replicate the relative complexity of endoscopic scoring ...

BACKGROUND Video capsule enteroscopy (VCE) has revolutionized small bowel imaging, enabling visual examination of the mucosa of the entire small bowel, while MR enteroclysis (MRE) and CT enteroclysis (CTE) have largely replaced conventional barium enteroclysis. A new indication for MRE and CTE is the clinical suspicion of small bowel strictures, as indicated by delayed or non-delivery of a test...

Background: Inflammatory bowel disease (IBD) therapy, including immunomodulatory (IMM), corticosteroids (CS), and TNF inhibitors (TNFI), is known to increase the infectious risk when used in to treat many diseases. No recent studies have analyzed the incidence of infections in elderly patients on these therapies. We aim to analyze the effect of immunosuppressant use and age on infectious compli...

Abstract Background Liver transplantation (LT) remains the only therapeutic option for patients with primary sclerosing cholangitis (PSC) who develop biliary tract complications or cirrhosis. Around 50-80% of PSC have IBD which represent phenotypically unique disease. Patients are prone to negative effects liver disease and immunosuppression, unpredictable course both diseases development neopl...

Abstract Background This study aimed to define clusters of disease activity and prognostic factors the course in a well-characterized cohort children with Crohn’s (CD). Methods All patients CD identified from SIGENP IBD registry follow-up at least 5 years 6-monthly evaluation were included. Active was defined for each yearly semester as follows: clinical (wPCDAI≥12,5 or MINI index ≥8), need tre...

disease: incidence, natural history and management in settings other than allogeneic stem cell transplantation. Haematologica 2005;90:1672-9. 2. Osawa R, Singh N. Cytomegalovirus infection in critically ill patients: a systematic review. Crit Care 2009;13:R68. 3. Torres HA, Aguilera E, Safdar A, et al. Fatal cytomegalovirus pneumonia in patients with haematological malignancies: an autopsy-base...

Motivation Results from genome-wide association studies (GWAS) suggest that a complex phenotype is often affected by many variants with small effects, known as 'polygenicity'. Tens of thousands of samples are often required to ensure statistical power of identifying these variants with small effects. However, it is often the case that a research group can only get approval for the access to ind...