Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor, primarily used for the treatment of hypertension, congestive heart failure, and heart attack. It belongs to BCS class III having a half-life of 12 hrs and 25% bioavailability. The purpose of the present work was to develop a press-coated, floating-pulsatile drug delivery system. The core tablet was formulated using the super-disint...

In the present work, fast disintegrating tablets of prochlorperazine maleate were prepared with a view to enhance patient compliance by direct compression method. Three superdisintegrants i.e., crospovidone, croscarmellose sodium and sodium starch glycolate in different ratios with MCC (Avicel, PH-102) along with directly compressible mannitol (Pearlitol SD 200) to enhance mouth feel. The prepa...

This study aimed to prepare tablets of black pepper extract using the Design Experiments (DOE) approach. The levels three factors—compressional force, croscarmellose sodium (CCS), and microcrystalline cellulose (MCC)—were screened one-factor-at-a-time technique, followed by DOE utilizing Box–Behnken design. respective variations for each factor were as follows: compressional force (1500–2500 ps...

The objective of this study was to evaluate and compare the effect of four superdisintegrants such as croscarmellose sodium (Ac-Di-Sol), crospovidone (Kollidon CL and with smaller particle sizes Kollidon CL-F), sodium starch glycolate (Explotab) in combination with β-lactose and microcrystalline cellulose (Avicel PH-102) as base excipients exhibiting properties of directly compressed tablets an...

BACKGROUND In the present investigation, an attempt was made to isolate starch from jackfruit seed powder and utilize it as a superdisintegrant to design fast dissolving tablets of irbesartan. METHODS Starch was isolated from jackfruit seeds via aqueous and alkali extraction processes and evaluated for its physicochemical properties, for phytochemical tests, and for acute toxicity studies. Ir...

Introduction. Herbal medicines are increasingly being used in the treatment of various diseases. Significant number resources, high-level availability and possibility cultivation have provided high prospects plant raw materials development new herbal medicines. Primula denticulate Smith. is one most interesting medicinal source modern medicine pharmacy with wide spectrum pharmacotherapeutic act...

Background: The main objective of present research work is to formulate the Carbamazepine as Fast Disintegrating tablets give fast relief and an increase in patient compliance. Carbamazepine, antiepileptic, belongs BCS Class-II used control some types seizures treatment epilepsy Neuropathic Pain by blocking use-dependent sodium channels.
 Methods: powdered materials were compressed direct ...

Objective: The study aimed to develop fast-dissolving films (FDFs) of the immunosuppressant drug tacrolimus monohydrate for sublingual administration, employing central composite design (CCD), improve its bioavailability. Methods: Tacrolimus: β-cyclodextrin inclusion complexes prepared earlier were formulated into FDFs. CCD was used developing optimal film formulation with desired characteristi...

Purpose: Inflammatory bowel disease (IBD) is a chronic, relapsing and often life-long disorder. The best way to tackle IBD is to develop a site targeted drug delivery. Methylprednisolone is a potent anti-inflammatory steroid. The relative potency of methylprednisolone to hydrocortisone is at least four is to one. The aim of the present research was to develop a colon targeted drug delivery for ...