A filamentous fungus, Cunninghamella elegans ATCC 9245, was used as a microbial model of mammalian metabolism to biotransform doxepin, a tricyclic antidepressant drug. Doxepin is produced as an 85:15% mixture of the trans- (E) and cis- (Z) forms. After 96 h of incubation in Sabouraud dextrose broth, 28% of the drug was metabolized to 16 metabolites. No change in the trans- (E) and cis- (Z) rati...

The incidence of pneumococcal bacteremia or meningitis in the period 1991–1994 was 8.3–9.2 cases per 100,000 personyears (table 1). In 1996, the incidence increased significantly to 14.8 cases per 100,000 person-years, and in 1997 to 13.3 (P = ); but in 1998 it returned to 8.9 cases per 100,000 person.0001 years. The incidence for the age group >65 years was approximately 4-fold higher and show...

Cunninghamella elegans grown on Sabouraud dextrose broth in the presence of naphthalene produced six metabolites. Each product was isolated and identified by conventional chemical techniques. The major metabolites were 1-naphthol (67.9%) and 4-hydroxy-1-tetralone (16.7%). Minor products isolated were 1,4-naphthoquinone (2.8%), 1,2-naphthoquinone (0.2%), 2-naphthol (6.3%), and trans-1,2-dihydrox...

During 2016–17, 277 samples of leaf compost, manure, virgin and rhizosphere soil of some plants from Fars and Khuzestan provinces (Iran) were transferred to Mycology Laboratory of the Department of Plant Protection, Shiraz University (Iran). Fungi were recovered by soil plate and soil dilution methods. After purification, the isolates of Mucorales were identified based on growth, morphological ...