*Dermatologist, Legacy Dermatology, Bountiful, UT **Dermatology Resident, PGY-3, Nova Southeastern University College of Osteopathic Medicine, Largo Medical Center, Largo, FL ***Osteopathic Medical Student, OMS-IV, Des Moines University College of Osteopathic Medicine, Des Moines, IA ****Dermatologist and Clinical Faculty, Nova Southeastern University College of Osteopathic Medicine, Largo Medi...

BACKGROUND Macular and lichen amyloidosis are clinical variants of primary localized cutaneous amyloidosis (PLCA). Most cases are sporadic, but approximately 10% of cases may be familial. To our knowledge, the clinicopathologic and molecular features of such pedigrees, however, have not been studied in detail. OBSERVATIONS We assessed 2 Brazilian families with either lichen-type (family 1 had...

Primary cutaneous amyloidosis (PCA) is a localized skin disorder that is characterized by the abnormal deposition of amyloid in the extracellular matrix (ECM) of the dermis. The pathogenesis of PCA is poorly understood. The objective of the present study was to survey proteome changes in PCA lesions in order to gain insight into the molecular basis and pathogenesis of PCA. Total protein from PC...

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. A 60-year-old woman showed blackish pigmentation around both eyes for 2 years, with clinical examination revealing waxy hyperpigmentation and small nodules (A). 12.7 mg/dL; and 24-hour urinary protein, 75 mg. A peripheral blood smear showed normocytic, normo...

A 52-year-old woman presented with a large partially yellow and erythematous tumor on her right temple. She reported that it had grown over the last 4 years. Regional lymph nodes were impalpable. A punch biopsy showed eosinophilic material in the dermis and subcutis. Immunohistochemistry showed positive staining for kappa and lambda light chains. Electron microscopy showed the typical amyloid f...