The deposition of immune complexes (IC) induces an acute inflammatory response with tissue injury. IC-induced inflammation is mediated by inflammatory cell infiltration, a process highly regulated by expression of multiple adhesion molecules. To assess the role of L-selectin and ICAM-1 in this pathogenetic process, the cutaneous reverse passive Arthus reaction was examined in mice lacking L-sel...

Prostaglandin E2 (PGE2) is produced in the skin and is suggested to play a role in the regulation of cutaneous immune homeostasis and responses. However, the multifaceted functions of PGE2 continue to elude our understanding, especially because of the multiplicity of PGE2 receptors--EP1, EP2, EP3, and EP4. While cAMP-elevating EP4 is known to activate the functions of cutaneous dendritic cells ...

Acne vulgaris is a common skin condition encountered in specialties outside of dermatology, including obstetrics and gynecology. The pathophysiology acne complex includes disruption the cutaneous microbiome, abnormal keratinization, inflammation, hormonal influences. Various topical systemic treatment modalities target each component pathophysiology. Clinically, can be broken down into noninfla...

The skin is the largest organ at the interface between the environment and the host with the function of mounting effective host defense. Microbiota and the host immune system are in permanent contact and communication via the skin. The complex relationship between the skin microbiome and cutaneous immunity is poorly understood, however recent evidence supports the idea that skin microbiota has...

Diabetes mellitus is a public health problem significantly contributing to morbidity and mortality worldwide. The patients are highly prone opportunistic infections with major systemic as well cutaneous fungi. fungal frequent in diabetics include Candidiasis Aspergillosis. most commonly involved species Aspergillus niger, flavus fumigatus. Presenting here case of 60 years male history diabetes ...

Protein kinase C (PKC) isoforms are major regulators of cutaneous homeostasis and mediate inflammation in response to 12-Otetradecanoylphorbol-13-acetate (TPA). We have previously reported that transgenic mice overexpressing PKC in the skin exhibit severe intraepidermal neutrophilic inflammation and keratinocyte apoptosis when treated topically with TPA. Activation of PKC increases the producti...

Sensory neurons innervating different tissues converge onto second-order neurons in the spinal cord. We examined whether inflammation or transient overexpression of nerve growth factor (NGF) in one tissue triggers hypersensitivity in referral sites. Thresholds to mechanical and thermal stimulation of the hindpaw, visceromotor responses to colorectal distension, and cystometrograms were performe...

Cutaneous polyarteritis nodosa (PAN) was first described by Lindberg in 1931. This initial description was followed by many case reports and series, including those of Díaz-Pérez and Winkelmann, who used a strict definition based on cutaneous involvement, and Chen and Daoud who classified the condition into three well differentiated groups. The cutaneous form of PAN is distinct from the systemi...

Inflammatory processes are associated with the rapid migration of dendritic cells (DCs) to regional lymph nodes and depletion of these potent antigen-presenting cells (APCs) from the inflamed tissue. This study examined whether sites of cutaneous inflammation can be repopulated with DCs from a pool of immature DCs circulating in the blood. In adoptive transfer experiments with ex vivo-generated...