PURPOSE Polyarteritis nodosa is one of the common forms of vasculitis with multiorgan involvement. Hearing loss may be the presenting symptom of this disease. The aim of this histopathologic study was to evaluate temporal bone changes in polyarteritis nodosa and assess the correlation between otologic manifestations and histopathologic findings. MATERIALS AND METHODS A retrospective human tem...

OBJECTIVES Recent research suggests that lysosomal-associated membrane protein-2 (LAMP-2) could be one of the target antigens in the pathogenesis of vasculitides. We established a transgenic rat model, env-pX rats, with various vasculitides including cutaneous vasculitis. Human primary cutaneous vasculitis includes cutaneous polyarteritis nodosa (CPN) and Henoch-Schönlein purpura (HSP). We meas...

POLYARTERITIs NODosA, as its niame implies, is ain inflammatory lesion involving the -whole three coats of the arterial system in a noclal manner. The causation of this is unknown, but its peculiar affinity for wi(despread involvement of the smaller arteries results in a multiplicity of clinical signs and symptoms, and leads to confusion and difficulty in diagnosis. The more severely affected o...

PURPOSE To demonstrate the neuroradiologic findings in patients with polyarteritis nodosa. METHODS A review of hospital records for a 10-year period revealed 50 patients with a discharge diagnosis of polyarteritis nodosa. Thirteen patients had undergone neuroimaging, and abnormal findings were found in 5 cases; these were the subjects of this study. RESULTS All 5 patients had abnormal findi...

Polyarteritis nodosa (PAN) is the systemic necrotizing vasculitis on small and median muscular vessels. Recent studies reveal that PAN consists of classical PAN and microscopic polyangitis (MPA). MPO-ANCA, which is one of anti-neutrophil cytoplasmic antibody (ANCA), is involved in the pathogenesis of MPA. In future, by the progress of research of ANCA, the definition or criteria of systemic vas...