نتایج جستجو برای: cxcl5
تعداد نتایج: 442 فیلتر نتایج به سال:
BACKGROUND Epithelioid, foam, and multinucleated giant cells (MNGCs) are characteristics of tuberculosis granulomas, yet the precise genesis and functions of these transformed macrophages are unclear. We evaluated the role of platelets as drivers of macrophage transformation in mycobacterial infection. METHODS We employed flow cytometry and microscopy to assess cellular phenotype and phagocyt...
The purpose of the present study was to investigate the effects of a 12-week training program on serum CXC ligand 5, tumor necrosis factor α (TNF-α) and insulin resistance index in obese sedentary women. To this end, twenty-four obese sedentary women were evaluated before and after a 12-week exercise program including a brief warm-up, followed by ~45 min per session of aerobic exercise at an in...
Bovine papillomavirus type 1 (BPV-1) and, less commonly, BPV-2 are associated with the pathogenesis of common equine skin tumors termed sarcoids. In an attempt to understand the mechanisms by which BPV-1 induces sarcoids, we used gene expression profiling as a screening tool to identify candidate genes implicated in disease pathogenesis. Gene expression profiles of equine fibroblasts transforme...
CXCR2 innon–small cell lung cancer (NSCLC) has been studiedmainly in stromal cells and is known to increase tumor inflammation andangiogenesis. Here, we examined the prognostic importance of CXCR2 inNSCLCand the role of CXCR2 and its ligands in lung cancer cells. The effect of CXCR2 expression on tumor cells was studied using stable knockdown clones derived from a murine KRAS/p53–mutant lung ad...
Gastroduodenitis caused by H. pylori, often acquired in early childhood, is found in about 50% of the adult population. Although H. pylori infections can remain asymptomatic, its virulence factors usually trigger epithelial vacuolization and degeneration, loss of microvilli, disintegration of cytoplasm, and leukocyte accumulation. It is believed that leukocyte infiltration is driven by cytokine...
Patients with COPD develop lung cancer more frequently than healthy smokers. At the same time, molecular mediators promoting various aspects of cancer cell progression are still elusive. In this report, we examined whether COPD can be coupled with increased migration of non-small-cell lung cancer cells A549 and, if so, whether this effect may be related to altered production and activity of che...
Crohnís disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases (IBD) with a chronic relapsing and remitting course. Both of them have a similar etiology, but differ in location and degree of intestinal injury (1). The pathogenesis of inflammatory bowel disease is complex, involving environmental, genetic, microbial, immune factors and mucosal permeability abnormalities (2). It...
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