The endothelial lining of the vasculature is exposed to a large variety of biochemical and hemodynamic stimuli with different gradients throughout the vascular network. Adequate adaptation requires endothelial cells to be highly plastic, which is reflected by the remarkable heterogeneity of endothelial cells in tissues and organs. Hemodynamic forces such as fluid shear stress and cyclic strain ...

The roles of cyclic nucleotide-gated (CNG) channels in sensory transduction have long been recognized. More recent studies found that CNG channels are distributed in multiple brain regions involved in memory and learning, including the cortex, hippocampus and cerebellum. These findings suggest that their functions are not limited to sensory perception, but also to neuronal plasticity phenomena,...

The roles of cyclic nucleotide-gated (CNG) channels in sensory transduction have long been recognized. More recent studies found that CNG channels are distributed in multiple brain regions involved in memory and learning, including the cortex, hippocampus and cerebellum. These findings suggest that their functions are not limited to sensory perception, but also to neuronal plasticity phenomena,...

Transcriptional changes in neurons underpin the long-lived cellular response to environmental stimuli, and cAMP-responsive element-binding protein (CREB1) has been implicated in this process. Exposure to psychostimulants such as cocaine results in persistent neuronal plasticity in cortical circuitry that likely modulates the motivation to use the drug again. To examine whether CREB1 in cortical...

Stiffness degradation and damping represent some of the most well-known aspects of cyclic soil behavior. While standard equivalent linear approaches reproduce these features by (separately) prescribing stiffness reduction and damping curves, in this paper a multiaxial visco-elastic-plastic model is developed for the simultaneous simulation of both cyclic curves over a wide cyclic shear strain r...

Hybrid fiber-reinforced polymer composites comprised of glass and steel fibers in a resin matrix have been shown to increased strength energy dissipation compared conventional composites. However, methods for simulating the mechanical behavior combinations hybrid yet be advanced. In this study, non-hybrid with off-axis were manufactured extracted coupons subjected half-cyclic tensile testing. T...