Distributor: Department of Organic Chemistry iii " Knowing without seeing is at the heart of chemistry. " – Roald Hoffman iv v Abstract This thesis concerns method development of new synthetic routes by applying electrophilic hypervalent iodine reagents, such as trifluoromethyl-benziodoxole (Togni reagent) and fluoro-benziodoxole. The first project involved the addition of an oxygen moiety and ...

A series of cycloalkene-annelated phthalazin-1(2H)-ones (2-5) was prepared in high yields by a one-pot procedure, employing pyridazino[4,5-d]pyridazin-1(2H)-ones (1) as azadienes and cyclic enamines as dienophiles in an inverse-electron-demand Diels-Alder reaction, followed by acid-catalyzed aromatization. Phthalazin-1(2H)-ones bearing a substituent at C-4 represent key intermediates in the syn...

Methane monooxygenase (MMO) catalyzes the oxidation of methane to methanol as the first step of methane degradation. A soluble NAD(P)H-dependent methane monooxygenase (sMMO) from the type II methanotrophic bacterium WI 14 was purified to homogeneity. Sequencing of the 16S rDNA and comparison with that of other known methanotrophic bacteria confirmed that strain WI 14 is very close to the genus ...

Protein glycosylation is a complex form of posttranslational modification and has been shown to be crucial for the function of many proteins. Sialic acid is prominently positioned at the outer end of membrane glycoproteins. It plays a critical role for the regulation of a myriad of cellular functions and it forms a shield around the cell. Furthermore, it constantly interacts with the environmen...

R ing-closing olefin metathesis (RCM) is an effective method for the formation of cyclic alkenes (1). Recently, the aromatization of RCM products has emerged as a topic of intensive investigation (2). In this context, a variety of regiocontrolled protocols have been developed for the synthesis of diverse heteroaromatic compounds, such as pyridines, pyridazines, pyrroles, quinolines, and furans ...

There is an ongoing hunt for biologically active compounds that can combat phytopathogenic fungi and improve plant growth without causing any hazards to the environment. Consequently the present study aims at deciphering the plant growth promotion and antifungal capability of Lysinibacillus sphaericus ZA9. The bacterium was previously isolated and identified in our laboratory from maize rhizosp...

-Hydroxybutyrate (GHB) is a psychotropic compound endogenous to the brain. Despite its potentially great physiological significance, its exact molecular mechanism of action is unknown. GHB is a weak agonist at GABAB receptors, but there is also evidence of specific GHB receptor sites, the molecular cloning of which remains a challenge. Ligands with high affinity and specificity for the reported...

The main synthetic routes towards vinylphosphonium salts and their wide applications in organic synthesis are discussed in this review. Particular attention is paid to the use of these compounds as building blocks for the synthesis of carbo- and heterocyclic systems after their prior transformation into the corresponding phosphorus ylides, followed by the intramolecular Wittig reaction with var...

Chromatographic analysis of amantadine was achieved using an Agilent J&W CP-Sil 8 CB column. Published by Elsevier B. V. Spatial Reorganization of Saccharomyces cerevisiae Enolase To Alter Carbon Metabolism under Hypoxia Eukaryotic Cell, 12, 1106-1119 (2013) Natsuko Miura et al. Tags CP-Sil 8 CB, clinical research Abstract Derivatized metabolites in a study of yeast hypoxia were analyzed by GC/...

The first examples of catalytic enantioselective ring-opening/cross-metathesis (EROCM) reactions that involve enol ethers are reported. Specifically, we demonstrate that catalytic EROCM of several oxaand azabicycles, cyclobutenes and a cyclopropene with an alkylor aryl-substituted enol ether proceed readily in the presence of a stereogenic-at-Mo monopyrrolide-monoaryloxide. In some instances, a...