نتایج جستجو برای: cyp2c19 polymorphism

تعداد نتایج: 108891  

Journal: :research in molecular medicine 0
naghi shahabi-majd faculty of medicine, mazandaran university of medical sciences, sari, postal code: 48471-91971, mazandaran, iran mohammad bagher hashemi-sotehoh faculty of medicine, mazandaran university of medical sciences, sari, postal code: 48471-91971, mazandaran, iran baharak habashi faculty of medicine, mazandaran university of medical sciences, sari, postal code: 48471-91971, mazandaran, iran mohammad reza shiran faculty of medicine, mazandaran university of medical sciences, sari, postal code: 48471-91971, mazandaran, iran

background: cytochrome p450 2c19 (cyp2c19) is a polymorphically expressed enzyme that shows marked interindividual and interethnic variation. cyp2c19*2 and cyp2c19*3 are the most frequently identified defective alleles in orientals and caucasian poor metabolizers (pm). the aim of this study was to investigate the frequencies of cyp2c19*1, cyp2c19*2 and cyp2c19*3 alleles and cyp2c19 genotypes in...

Journal: :British journal of clinical pharmacology 2009
Jyh-Chin Yang Yu-Fan Yang Yow-Shieng Uang Chun-Jung Lin Teh-Hong Wang

AIMS The aim was to explore the role of CYP2C19 polymorphism in short-term rabeprazole-based triple therapy against Helicobacter pylori infection. METHODS Patients with H. pylori infection were tested for CYP2C19 genotype as poor metabolizers (PMs) or extensive metabolizers (EMs, homozygous EM or heterozygous EM) and given rabeprazole for 7 days. Antibiotics (clarithromycin and amoxicillin) w...

Journal: :Molecules 2021

Clopidogrel is a widely-used antiplatelet drug. It important for the treatment and prevention of coronary heart disease. can effectively reduce platelet activity therefore stent thrombosis. However, some patients still have ischemic events despite taking clopidogrel due to alteration in metabolism attributable various genetic non-genetic factors. This review aims summarise mechanisms causes res...

Journal: :BMC Clinical Pharmacology 2007
Carlos Isaza Julieta Henao José H Isaza Martínez Juan C Sepúlveda Arias Leonardo Beltrán

BACKGROUND Omeprazole is metabolized by the hepatic cytochrome P450 (CYP) 2C19 enzyme to 5-hydroxyomeprazole. CYP2C19 exhibits genetic polymorphisms responsible for the presence of poor metabolizers (PMs), intermediate metabolizers (IMs) and extensive metabolizers (EMs). The defective mutations of the enzyme and their frequencies change between different ethnic groups; however, the polymorphism...

Journal: :Journal of biochemistry and molecular biology 2007
Soo-Youn Lee Seung-Tae Lee Jong-Won Kim

We examined the contribution of CYP2C9 and CYP2C19 genotypes and drug interactions to the phenytoin metabolism among 97 Korean epileptic patients to determine if pharmacogenetic testing could be utilized in routine clinical practice. The CYP2C9 polymorphism is a wellknown major genetic factor responsible for phenytoin metabolism. The CYP219 polymorphism, with a high incidence of variant alleles...

2015
You-quan Wei Dian-gang Wang Hao Yang Heng Cao Carmine Pizzi

BACKGROUND The cytochrome P450 (CYP450) 2C19 681 genotypes affect the antiplatelet activity of clopidogrel. We investigated the correlation of CYP 2C19 681G > A mutation with clopidogrel resistance (CR). Additionally, we studied the effect of CR on clinical prognosis of patients with acute coronary syndrome (ACS). METHODS One hundred ten ACS patients undergoing percutaneous coronary intervent...

2017
J.F.M. Marchini M.R. Pinto G.C. Novaes A.V. Badran R.B. Pavão G.L. Figueiredo I.M. Lago M.O. Lima-Filho D.C. Lemos M. Tonani C.M. Antloga L. Oliveira J.C. Lorenzi J.A. Marin-Neto

Clopidogrel and aspirin are the most commonly used medications worldwide for dual antiplatelet therapy after percutaneous coronary intervention. However, clopidogrel hyporesponsiveness related to gene polymorphisms is a concern. Populations with higher degrees of genetic admixture may have increased prevalence of clopidogrel hyporesponsiveness. To assess this, we genotyped CYP2C19, ABCB1, and P...

Journal: :Genetics and molecular research : GMR 2016
D D Nabinger L E Mazzoleni G B Sander F Mazzoleni M C Osório M G Klein T F Rech L Basso da Silva G S de Moraes R A Cristovam E F Nardelli C F M Francesconi D Simon

The aim of this study was to examine the effect of polymorphisms in the cytochrome P450 (CYP) 2C19 gene (CYP2C19) on the Helicobacter pylori eradication rate in Brazilian patients with functional dyspepsia. Adults diagnosed with functional dyspepsia based on the ROME III criteria and infected with H. pylori were recruited to this study. The patients were subjected to gastrointestinal endoscopy ...

2011
Yogita Ghodke Kalpana Joshi Bhushan Patwardhan

Traditional Indian medicine-Ayurveda-classifies the human population into three major constituents or Prakriti known as Vata, Pitta and Kapha types. Earlier, we have demonstrated a proof of concept to support genetic basis for Prakriti. The descriptions in Ayurveda indicate that individuals with Pitta Prakriti are fast metabolizers while those of Kapha Prakriti are slow metabolizers. We hypothe...

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