نتایج جستجو برای: cytogenetic
تعداد نتایج: 12450 فیلتر نتایج به سال:
BACKGROUND Acute lymphoblastic leukemia (ALL) is the sixth most common malignancy in Iran. Cytogenetic analysis of leukemic blasts plays an important role in classification and prognosis in ALL patients. The purpose of this study was to define the frequency of chromosomal abnormalities of ALL patients in adults and children in Fars province, Iran. METHODS In this cross-sectional study, we eva...
BACKGROUND Cytogenetic abnormalities (CAs) have been reported frequently in patients with otherwise typical aplastic anemia (AA), but their implications in the prognosis and in the evolution to hematologic malignancies are controversial. METHODS We retrospectively analyzed 127 adult AA patients who had successful cytogenetic analysis at initial diagnosis. RESULTS The patients were classifie...
PURPOSE Most patients with chronic-phase chronic myeloid leukemia (CML) who receive imatinib achieve a complete cytogenetic remission (CCgR) and low levels of BCR-ABL transcripts. CCgR is durable in the majority of patients but relapse occurs in a subset. EXPERIMENTAL DESIGN To determine the potential of quantitative reverse transcription-PCR of BCR-ABL to predict cytogenetic relapse, we seri...
OBJECTIVE To evaluate the response of Imatinib mesylate in patients with myeloid leukemia in chronic accelerated and blast phase. PATIENTS AND METHODS Eleven patients with established diagnosis of chronic myeloid leukemia were treated with Imatinib mesylate. Adverse events were documented with regular follow ups. Hematological and cytogenetic responses were assessed according to established c...
Cytogenetic abnormalities at diagnosis are important prognostic indicators in acute myeloid leukemia (AML). AML is categorized into 3 risk groups according to cytogenetic abnormalities; favorable, intermediate, and unfavorable. A new cytogenetic risk group called the monosomal karyotype (MK) had been identified in AML in the unfavorable cytogenetic risk group. The MK was reported to be associat...
Imatinib mesylate provides good results in the treatment of CML in general. But what about the results of this treatment in CML associated with additional cytogenetic abnormalities at diagnosis among black Africans? For this, we retrospectively studied 27 cases of CML associated with additional cytogenetic abnormalities, diagnosed in the department of clinical hematology of the University Hospi...
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