We describe a case in which a patient immunocompromised by acute myeloid leukemia experienced acute fulminating invasive fungal sinusitis followed by pneumonia and then death. Though the microbiology of the pneumonia could not be directly investigated, nasal lesions revealed fungal mycelium. Valsa sordida was consistently cultured from a biopsied sample. The fungus was identified to the genus l...

BACKGROUND BACE1 was found to be the major β-secretase in neurons and its appearance and activity were found to be elevated in the brains of AD patients. Fungal endophytic extracts for BACE1 inhibitory activity and cytotoxicity against PC-12 (a rat pheochromocytoma with neuronal properties) and WRL68 (a non-tumorigenic human hepatic) were investigated. METHODS Endophytes were isolated from pl...

BACKGROUND The plant pathogenic fungus (such as Gibberella zeae, Fusarium oxysporum and Cytospora mandshurica) causes devastating disease in agriculture. The pathogenic fungus is responsible for billions of dollars in economic losses worldwide each year. In order to discover new fungicidal molecule with good fungicidal activity against G. zeae, F. oxysporum, and C. mandshurica, we sought to com...

A series of novel sulfone derivatives containing 1,3,4-oxadiazole moiety were synthesized. All the target com-pounds were characterized by H and C nuclear magnetic resonance, infrared spectroscopy and elemental analysis. Their antifungal activities were tested in vitro with six important phytopathogenic fungi, namely, Gibberella zeae, Fusarium oxysporum, Cytospora mandshurica, Phytophthora infe...

We found a n error in F igure 1 in our paper publis hed in the Marine Drugs [1]. The structure of Cytosporones A and B are corrected as follows. A dditional chemistry details of these com pounds can be found in our earlier paper [2]. Figure 1. Chemical structures of cytosporones A and B in figure 1. O CH 3 OH OH Cytosporone A (R = H) Cytosporone B (R = Et)) O RO We apologize for any inconvenien...