the one-pot, multi-component synthesis of 4,4′-(arylmethylene)bis(1h-pyrazol-5-ols) by tandem knoevenagel-michael reaction of phenylhydrazine, ethyl acetoacetate and aldehydes in the presence of silica-bonded n-propylpiperazine sulfamic acid (sbppsa) as a recyclable solid acid catalyst was reported. sbppsa showed much the same efficiency when used in consecutive reaction runs.

abstract objective ethylmalonic encephalopathy (ee) is a severe mitochondrial disease of early infancy clinically characterized by a combination of developmental delay, progressive pyramidal signs and vascular lesions including petechial purpura, orthostatic acrocyanosis and chronic hemorrhagic diarrhoea. biochemical hallmarks of the disease are persistently high levels of lactate, and c4–c5-ac...

surface oxidized carbon vulcane xc-72 is prepared as catalyst support and platinumnanoparticles are chemically anchored onto the modified surface. the nanoparticles of pt weresynthesized by reduction of h2ptcl6 with sodium borohydride in a 5.5 m buffer solution ofsodium citrate; the complexation of citrate with metal ions is beneficial to the formation ofnanoparticles. the electro-oxidation of ...

background: drug nano-carriers are one of the most important tools for targeted cancer therapy so that undesired side effects of chemotherapy drugs are minimized. in this area, the use of ultrasound can be helpful in controlling drug release from nanoparticles to achieve higher treatment efficiency. objective: here, we studies the effects of ultrasound irradiation on the release profile of 5-fl...

this study was designed to assess the role of first-line chemotherapy with 5-fu and platinum in the treatment of advanced or recurrent cervical cancer, ten patients with advanced or recurrent cancer of the cervix, with no prior chemotherapy were entered in phase ii trial, from oct. 2000 to nov. 2001. eight patients were treated with cis-platinum (50 mg/m2 over 60 minutes in first day) followed ...

objective : the purpose of this study was to determine the construct validity and reliability of the two forms of the persian version of the difficulties in emotion regulation scale (ders-6 & ders-5-revised) in a clinical sample. methods : the clinical sample consisted of 181 patients diagnosed with functional gi disorders (fgid) who referred to the digestive psychosomatic clinic in isfahan in ...

the number and function of human natural killer (nk) cells are generally assessed to monitor the baseline of immune function, the effect of treatment, the progress of malignancy or metastases and diseases. nk cells recognise and kill target cells in the absence of prior sensitisation and are able to defend the host from infection or prevent the progression of a disease. human nk cells express c...

objective(s): ten-eleven translocation (tet) family members have been shown to be involved in the development of many tumors. however, the biological role of the tet family and its mechanism of action in colorectal carcinogenesis and progression remain poorly understood. materials and methods:we measured the expression levels of tet family members in colorectal cancer (crc) specimens, in the co...

background: breast cancer is one of the main life-threatening diseases which a woman may face during her life. several lifestyle factors such as weight gain, obesity, fat intake and decreased level of physical activity are associated with breast cancer risk.   in vitro and vivo studies showed that, linoleic acid (la) is one of the main fatty acids composition of nigella sativa. the objective wa...