Methamphetamine users are at increased risk of hepatitis A, but modes of transmission are unclear. The authors conducted a case-control study among methamphetamine users during an outbreak in Iowa in 1997. Twenty-eight reported, laboratory-confirmed, hepatitis A cases did not differ from 18 susceptible controls with respect to age, sex, or number of doses used. When compared with controls in mu...

Early-onset methamphetamine use increases the lifetime prevalence of methamphetamine dependence. An earlier onset of methamphetamine use leads to greater damage to the terminal ends of serotonin neurons, more reduction in serotonin transporter (5-HTT) density, and an increased propensity toward further methamphetamine use. Because the 5-HTT-linked polymorphic region (5'-HTTLPR) within the promo...

Methamphetamine is a highly addictive psychostimulant drug of abuse that causes neurotoxicity with high or repeated dosing. Earlier studies demonstrated the ability of the selective σ receptor ligand N-phenethylpiperidine oxalate (AC927) to attenuate the neurotoxic effects of methamphetamine in vivo. However, the precise mechanisms through which AC927 conveys its protective effects remain to be...

BACKGROUND The C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) is a nontoxic peptide with demonstrated in vitro and in vivo neuroprotective effects against striatal dopaminergic damage induced by 1-methyl-4-phenylpyridinium and 6-hydoxydopamine, suggesting its possible therapeutic potential in Parkinson's disease. Methamphetamine, a widely abused psychostimulant, has selective d...

abstract         background and objective: methamphetamine has strong stimulating effects on various systems of the human body. the aim of this study was to evaluate the hematological and biochemical parameters in methamphetamine addicts and to compare them with healthyindividuals.      methods: this is a retrospective case-control study that was conducted in 1390-91 in ibn sina hospital in shi...

Dear Editor, Methamphetamine is a potent neurotoxin which can cause dopaminergic degeneration.1 In emergency department settings of hospitals, common presenting symptoms relating to Methamphetamine intoxication include chest pain, hypertension, shortness of breath, and tachycardia.2 In Iran, Methamphetamine intoxication has recently emerged as a crucial health problem in clinical and therapeuti...

OBJECTIVES To determine the prevalence and factors of Viagra use in combination with crystal methamphetamine and its association with HIV risk behavior in a probability sample of men who have sex with men (MSM). STUDY DESIGN A cross-sectional, random-digit dial telephone survey of MSM in San Francisco conducted between June 2002 and January 2003. RESULTS Of the 1976 MSM, 13.5% used Viagra a...

Methamphetamine and related amphetamine compounds are among the most commonly used illicit drugs, with over 35 million users worldwide. In the United States, admissions for methamphetamine treatment have increased dramatically over the past 10 years. Methamphetamine use is prevalent among persons with HIV infection and persons at risk for HIV, particularly among men who have sex with men. In ad...

a b s t r a c t abstract- methamphetamine has rapidly become more prominent in iran, which is now second most common drug behind heroin. moreover, initiation of methamphetamine abuse is a major cause of failure of opioid treatment programs such as methadone maintenance treatment. this calls for development of more effective treatment methods for methamphetamine addiction, and especially develop...

introduction: using addictive drugs can change the amount of neurotransmitters, especially dopamine and glutamate. glutamate has been known to trigger the relapse and tendency toward addictive drugs. the glutamate receptor ionotropic nmda type subunit 1 (grin1) contains the single- nucleotide polymorphism c1001g (rs11146020) and encodes n-methyl-d-aspartic acid (ndma) receptor subunit 1 (nr1). ...