D-type cyclins (cyclins D1, D2, and D3) are regarded as essential links between cell environment and the core cell cycle machinery. We tested the requirement for D-cyclins in mouse development and in proliferation by generating mice lacking all D-cyclins. We found that these cyclin D1(-/-)D2(-/-)D3(-/-) mice develop until mid/late gestation and die due to heart abnormalities combined with a sev...

In this paper we present a soft computing system developed to optimize the laser milling manufacture of high value steel components, a relatively new and interesting industrial technique. This multidisciplinary study is based on the application of neural projection models in conjunction with identification systems, in order to find the optimal operating conditions in this industrial issue. Sens...

Cold-formed structural sections are manufactured at ambient temperature and hence undergo plastic deformations which result in an increase in the yield stress and ultimate stress, but reduced ductility. This paper begins with a comparative study of existing predictive models to harness this strength increase. Modifications to the existing models are then made and an improved model is presented....

During germ-cell migration in the mouse, the dynamics of embryo growth cause many germ cells to be left outside the range of chemoattractive signals from the gonad. At E10.5, movie analysis has shown that germ cells remaining in the midline no longer migrate directionally towards the genital ridges, but instead rapidly fragment and disappear. Extragonadal germ cell tumors of infancy, one of the...

BACKGROUND Hypocalcemia is a frequent abnormality that has been associated with disease severity and outcome in hospitalized foals. However, the pathogenesis of equine neonatal hypocalcemia is poorly understood. Hypovitaminosis D in critically ill people has been linked to hypocalcemia and mortality; however, information on vitamin D metabolites and their association with clinical findings and ...

Among other factors, the precision of dental impressions is an important and determining factor for the fit of dental restorations. The aim of this study was to examine the three-dimensional (3D) precision of gypsum dies made using a range of impression techniques and materials. Ten impressions of a steel canine were fabricated for each of the 24 material-method-combinations and poured with typ...

Ultrasonic elliptical vibration cutting has recently been utilized in industry for finishing of various precision parts such as mirror surface finishing and precision micro machining of dies and molds. However, its application has been limited to high-cost ultra-precision machining, where depth of cut is typically in a range from a few micrometers to several tens of micrometers due to power lim...