The effects of patent ductus arteriosus upon the circulation were studied by Eppinger, Burwell, and Gross (1). Later, Dexter, Haynes, Burwell, Eppinger, Sosman, and Evans (2) described preoperative and postoperative hemodynamic studies obtained by cardiac catheterization in a patient with patent ductus arteriosus. Since the presence of a patent ductus arteriosus can. be detected by physical exa...

The physiological role of endothelin-1 (ET-1) in regulation of vascular tone in the perinatal lung is controversial. Recent studies suggest that ET-1 contributes to high basal pulmonary vascular resistance in the normal fetus, but its role in the modulation of pulmonary vascular tone remains uncertain. We hypothesized that high ET-1 activity opposes the vasodilator response to some physiologica...

Isolated mycotic saccular aneurysm of the left pulmonary artery as a result of acute bacterial endarteritis complicating persistent ductus arteriosus is described in 2 children aged I3 years and 7 years. Successful resection of the aneurysm was accomplished in the first child. The second child had associated aortic incompetence and succumbed from cardiac failure while awaiting operation. Aneury...

Duration of ductal shunting in healthy preterm infants: an echocardiographic color flow Doppler study. Early echocardiographic prediction of symptomatic patent ductus arteriosus in preterm infants undergoing mechanical ventilation. Re-evaluation of the left atrial to aortic root ratio as a marker of patent ductus arteriosus. Selective head cooling with mild systemic hypothermia after neonatal e...

Introduction Ibuprofen is used widely to close patent ductus arteriosus in preterm infants. The anti-inflammatory activity of ibuprofen may also be partly due to its ability to scavenge reactive oxygen species and reactive nitrogen species. We evaluated the interaction between oxidative status and the medical treatment of patent ductus arteriosus with two forms of ibuprofen. Materials and metho...

W HEN there is a right-sided aortic arch, persistence of a left-sided ductus arteriosus can readily be demonstrated by angiocardiography. This is important because in some types of eyanotic congenital heart disease, such as in the tetralogy of Fallot, anl artificial aortico-pulmonary (Blalock-Taussig' or Pott S2 shunt) is often created in order to alleviate the distress produced by anoxia. Two ...

INTRODUCTION Restoration of blood flow through a previously occluded ductus arteriosus may occur in some patients. Treatment strategy in patients with such residual shunts has not yet been uniformly established. AIM To present single-centre experience and to attempt to establish a strategy of management of patients with residual ductus arteriosus shunts following percutaneous closure. METHO...

Patent ductus arteriosus (PDA) is the most prevalent cardiovascular defect and is more often seen in females; premature babies are at increased risk. For both sexes, a relationship exists between the risk of this defect occurring and the higher dimensions of the ductus arteriosus. In this study, we examined the relationship between the dimensions of the ductus arteriosus (diameter, length, capa...

background: closure of patent ductus arteriosus (pda), ventricular septal defect (vsd) and atrial septal defect (asd) can be done surgically or by device. this study was designed to compare the total cost of surgical or device closures of pda, asd or vsd for iranian patients. methods: this is a cross-sectional study, conducted from january 1, 2005 until january 1, 2006 in two large heart center...

A successful correction of type I truncus arteriosus using a 12 mm 'dacron' conduit containing a porcine aortic valve (Hancock) between the right ventricle and the pulmonary artery in a 6-month-old infant is reported. The rationale for the treatment of truncus arteriosus in infancy is discussed.