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BACKGROUND Multidetector computed tomography is useful for determining the appropriate transcatheter heart valve (THV) size in patients with severe aortic stenosis who are suboptimal surgical candidates. The relationship between adherence to the recommended CoreValve sizing algorithm and clinical outcomes is not known. METHODS AND RESULTS We evaluated 1023 patients with severe aortic stenosis...

Habitat fragmentation may strongly affect species density, species interactions, and the rate of ecosystem processes. It is therefore important to understand the observed variability among species responses to fragmentation and the underlying mechanisms. In this study, we compare density-area relationships (DARs) for 344 lepidopteran species belonging to 22 families (butterflies and moths). Thi...

Aim: I extend the traditional SAR, which has achieved status of ecological law and plays a critical role in global biodiversity assessment, to the general (alphaor beta-diversity in Hill numbers) diversity area relationship (DAR). The extension was motivated to remedy the limitation of traditional SAR that only address one aspect of biodiversity scaling—species richness scaling over space. Inno...

Allatostatins (ASTs) are multifunctional neuropeptides that generally act in an inhibitory fashion. ASTs were identified as inhibitors of juvenile hormone biosynthesis. Juvenile hormone regulates insect metamorphosis, reproduction, food intake, growth, and development. Drosophila melanogaster RNAi lines of PheGlyLeu-amide-ASTs (FGLa/ASTs) and their cognate receptor, Dar-1, were used to characte...

This paper presents a performance analysis of ATM routing with nonlinear equivalent capacity in symmetric and fully connected network. The conventional dynamic alternative routing (DAR) is here extended to the environment of multiple services with nonlinear equivalent capacity. This extension uses the trunk reservation policy and dynamic service/route separation. The analytical model of general...

Background: It is believed that the loading value of anticancer drug conjugated to the monoclonal antibody, called drug-to-antibody ratio (DAR), is the main quality feature of antibody-drug conjugates. Methods: In this study, matrix assisted laser desorption/ionization mass spectrometry was used to determine the average molecular weight of trastuzumab and its three conjugated forms. The differe...

Dieses Positionspapier stellt eine Zusammenfassung der gegenwärtigen Arbeitsergebnisse die im Fraunhofer Institute FOKUS erzielt wurden dar