Even with multidisciplinary treatment, the prognosis and quality of life of patients diagnosed with head and neck squamous cell carcinoma (HNSCC) are still not satisfactory. Previously, 19-Nor-2α-(3-hydroxypropyl)-1α,25(OH)2D3 (MART-10), the new brand 1α,25(OH)2D3 analog, has been demonstrated to be an effective drug to inhibit HNSCC growth in vitro. Since most cancer patients die of metastasis...

Regarding breast cancer treatment, triple negative breast cancer (TNBC) is a difficult issue. Most TNBC patients die of cancer metastasis. Thus, to develop a new regimen to attenuate TNBC metastatic potential is urgently needed. MART-10 (19-nor-2α-(3-hydroxypropyl)-1α,25(OH)₂D₃), the newly-synthesized 1α,25(OH)₂D₃ analog, has been shown to be much more potent in cancer growth inhibition than 1α...

We evaluated the expression of vimentin, S100a, and Melan A/MART-1 (melanoma antigen recognized by T cells 1) in seven cell lines established independently from dogs with canine melanoma. We also compared routine immunostaining of 29 clinical specimens from melanoma cases using vimentin, S100a, and neuron-specific enolase (NSE) with staining for Melan A/MART-1 as part of a diagnostic panel. All...

Wal-Mart is one of the most extraordinary success stories in business history. Started in 1962 by Sam Walton, Wal-Mart has grown to become the world's largest corporation. In the financial year ending January 31, 2004, the discount retailer whose mantra is " every day low prices " had sales of nearly $256 billion, five thousand stores in ten countries (almost three thousand are in the United St...

Uveal melanoma (UM) is one of the most common primary intraocular malignant tumors in adults. Melanoma antigen recognized by T cell-1 (Mart-1), one of the melanosome-specific proteins, has been widely studied as a marker recognized by cytotoxicity T lymphocytes. Mart-1 is considered to play a critical role in the immunotherapy for melanoma. Additionally, as a biomarker, Mart-1 is often used wit...

Structural Health Monitoring (SHM) system requires a fast and accurate algorithm for defect detections in the large structures like aircraft skins for which Lamb wave tomography (LWT) appears to be very powerful technique, as their propagation properties depend on the thickness and the mechanical properties of the material. Projection data is collected by electronically scanning an array of ult...

PURPOSE Downregulation of melanoma-associated antigens (MAAs), against which natural cytolytic T lymphocytes (CTLs) exist in humans, is one of the mechanisms that aids in evasion of immune surveillance. In view of putative re-expression strategies for MAAs during immunotherapy, this study was conducted to investigate MAA silencing in malignant melanoma. METHODS The expression of the MAA Melan...

This empirical study is mainly devoted to comparing four tree-based boosting algorithms: mart, abc-mart, robust logitboost, and abc-logitboost, for multi-class classification on a variety of publicly available datasets. Some of those datasets have been thoroughly tested in prior studies using a broad range of classification algorithms including SVM, neural nets, and deep learning. In terms of t...

Previous academic research on the expansion of dominant retailers such as Wal-Mart has looked at implications for incumbent retailers, consumers, and the local community. Little is known, however, about Wal-Mart’s influence on suppliers’ performance. Manufacturers suggest Wal-Mart uses its power to squeeze their profits. In this paper we study the validity of that claim. We investigate the unde...

Over the past decade, many efforts have been made to identify MHC class II-restricted epitopes from different tumor-associated Ags. Melan-A/MART-1(26-35) parental or Melan-A/MART-1(26-35(A27L)) analog epitopes have been widely used in melanoma immunotherapy to induce and boost CTL responses, but only one Th epitope is currently known (Melan-A51-73, DRB1*0401 restricted). In this study, we descr...