The culture media optimization is an inevitable part of upstream process development in therapeutic monoclonal antibodies (mAbs) production. The quality by design (QbD) approach defines the assured quality of the final product through the development stage. An important step in QbD is determination of the main quality attributes. During the media optimization, some of the main quality attribute...

In an earlier column, I compared the roles of a software architect and a traditional building architect. I suggested that this oftenused analogy may not be entirely accurate, and that there may be a more precise analogy available to us in the emerging field of architectural engineering. In a subsequent release of SEI Interactive, Rick Kazman continued contrasting software architecture and “trad...

Recent meat demand models incorporate demand functions for cuts of meat rather than whole carcasses. However, parameters for “meat quality” are seldom included in such models. Modelling difficulty arises as meat cuts are heterogeneous in their quality attributes. Meat quality may be assessed by measurement of attributes including tenderness, juiciness and flavour. Cooking method and cooking tim...

in spain, camping accommodation accounted for 6.32% of total tourism accommodation and 8.2% of overnight stays in 2007. there were 1,152 registered campsites which provided lodging for almost 6.4 million users. although these figures are higher than those of rural accommodation, few studies have analyzed the main attributes of this sector and their contribution to the development of spanish tou...

We present an overview of our approach to managing security as a dimension of Quality of Service. Relative to traditional QoS attributes (e.g., jitter, deadline, latency) security has been handled rather statically and indirectly. We have developed a theory of Quality of Security Service and a related security-costing framework that supports extension of QoSS functionality to embrace existing a...

Importanceeperformance analysis (IPA) is a popular customer-driven tool that enables companies to understand market competition and identify improvement priorities for various attributes of products and services. Despite the widespread use of IPA, previous studies have identified specific deficiencies. For example, the managerial improvement directions derived from IPA are potentially misleadin...

Timely adoption of new varieties is critical to profitable peach production, and peach quality is a primary factor driving adoption. An adoption model for peach varieties is estimated, incorporating grower evaluations of peach quality. The model identifies the impact of farm characteristics such as the farmer's quality preferences, on-farm agronomic and orchard conditions, as well as geographic...