The transgenic rat TGR(mRen2)27 is a new monogenetic model in hypertension research that develops fulminant hypertension after the mouse Ren-2d renin gene has been integrated into its genome. To evaluate the molecular mechanism of development of hypertension in this animal model, we measured cytosolic free sodium concentration in intact lymphocytes from seven transgenic rats and eight age-match...

Continuously performing heavy activities will damage tissues and cells cause oxidative stress. Fortunately, this can be reduced by giving antioxidants to reduce free radicals. This study uses the forced swimming test model determine effect of Javanese ginseng root extract on superoxide dismutase levels in male white Sprague Dawley rats. The samples were 30 rats divided into five groups: negativ...

Purpose: To investigate the effect of quaternary amines on myocardial cells a rat model cardiac arrest, with respect to energy generation potential and oxygen free radicals.
 Methods: Forty-five Sprague-Dawley (SD) rats were assigned sham, amine groups (each 15 rats). After their corresponding treatments, lectrocardiogram (ECG) monitoring in three at various time periods was carried out. S...

The objective of this study was to examine whether ultrasound can the development cerebral vascular structure and blood flow in Sprague–Dawley (SD) rats by a noninvasive manner, which provides reference for research SD rats. Thirty-nine (7–16 days old) were divided into seven groups according age, number each group was, respectively, 7, 17, 1, 3, 2, 8, 1. Ultrasound used detect vessels, cerebro...

Purpose: To investigate the effect of S-adenosyl-L-methionine (SAM) on angiogenesis and fibrosis in heart rats with myocardial infarction (MI), to determine mechanism action.Methods: Sprague Dawley MI received SAM treatment (15 mg/kg) intraperitoneally. The cumulative survival (%) was recorded their rate survival. Hematoxylin-eosin staining, echocardiography, hemodynamics were also performed. I...

Qualitative and quantitative differences of purified hepatic 3 alpha-hydroxysteroid UDP-glucuronosyltransferase were investigated in Wistar and Sprague-Dawley rats. Individual differences in the glucuronidation rate of androsterone and chenodeoxycholic acid were observed in hepatic microsomal fractions from Wistar but not Sprague-Dawley rats. No individual variation was observed in the glucuron...

Spike-and-wave discharge is an electroencephalographic brainwave found in many rodent species and studied rigorously in inbred laboratory rats (WAG/Rij and GAERS strains) for its similarities to absence epilepsy. The absence epilepsy research field, however, is divided on just how similar SWD in rats is to absence epilepsy in humans. Albino Sprague Dawley rats are an outbred strain used in many...

The experimental carcinogenesis results in six compounds related to vinyl chloride are reported. Vinylidene chloride, given by inhalation, was carcinogenic in male CD-1 mice, male CD rats, Sprague-Dawley rats and male Swiss mice. Trichloroethylene, given by gavage and inhalation, was carcinogenic in the B6C3F1 mice. When given by gavage, perchloroethylene was carcinogenic in the B6C3F1 mice, an...

we aimed to evaluate the potential of growing rats as a model of osteoporosis induced by short term hypercholesterolemia. twelve growing female sprague-dawley rats were randomly allocated into two groups. control rats received standard diet while rats in group 2 were fed with diet contained 20% sunflower oil, 2% cholesterol and 0.5% cholic acid for 2 weeks and then a diet contained 10% sunflowe...

To explore the effect of monosialotetrahexosylganglioside sodium on cortical neurogenesis in traumatic brain injury rats. Thirty Sprague–Dawley rats were randomly divided into control group, saline group and group. The model was prepared with hydraulic controllable device received sham operation. levels oxidative stress, nerve damage, new born neurons, learning memory capabilities assessed seru...