An unusual polyketide with a new carbon skeleton, lindgomycin (1), and the recently described ascosetin (2) were extracted from mycelia and culture broth of different Lindgomycetaceae strains, which were isolated from a sponge of the Kiel Fjord in the Baltic Sea (Germany) and from the Antarctic. Their structures were established by spectroscopic means. In the new polyketide, two distinct domain...

Poly-12-hydroxystearic acid (PHSA) is widely used as a coating on colloidal spheres to provide a "hard-sphere-type" interaction. These hard spheres have been widely used in fundamental studies of nucleation, crystallization, and glass formation. Most authors describe the interaction as "nearly" hard sphere. In this paper we directly measure this interaction, using layers of PHSA adsorbed onto m...

The absolute stereostructure of luminamicin, an anaerobic antibiotic, has been determined by using conformational analysis via high-temperature molecular dynamics, NMR spectroscopy, and the modified Mosher method. It was found that luminamicin has the S, S, R, R, R, R, S, S, S, R, and S configurations at C2, C4, C7, C9, C10, C11, C12, C13, C16, C28, and C29, respectively. This configuration is ...

Non-aqueous microgel particles are commonly synthesised in water, dried, and then redispersed in non-aqueous solvents. An important factor to consider when synthesising such particles is the initiator, which can determine how well the particles disperse in solvents. Polystyrene microgel particles were made with three different initiators. When a neutral, oil soluble initiator (azobisisobutyroni...

Several kalihinol natural products, members of the broader isocyanoterpene family of antimalarial agents, are potent inhibitors of Plasmodium falciparum, the agent of the most severe form of human malaria. Our previous total synthesis of kalihinol B provided a blueprint to generate many analogues within this family, some as complex as the natural product and some much simplified and easier to a...

A calorimetric method of obtaining directly the fragility of liquids from the fictive temperatures of variably quenched glasses, is outlined. "Steepness indexes" m, have been determined for a group of molecular liquids of diverse character, and vary in the range 50-150. The values obtained mostly agree well with those from earlier studies using dielectric relaxation, heat capacity spectroscopy,...

Fusarium graminearum is a causal organism of head blight in cereals and maize. Although few secondary metabolites produced by F. are considered disease virulence factors, many molecular products biosynthetic gene clusters expressed during infection their associated role the unknown. In particular, predicted meroterpenoid cluster historically designated as “C16” likely with pathogenicity. Presen...

Nanosized amorphous alloy powders of Fe20Ni80 , Fe40Ni60 , and Fe60Ni40 were prepared by sonochemical decomposition of solutions of volatile organic precursors, Fe~CO!5 and Ni~CO!4 in decalin, under an argon pressure of 100 to 150 kPa at 273 K. Magnetic susceptibility of Fe40Ni60 and Fe60Ni40 indicates blocking temperatures of 35 K and a magnetic particle size of about 6 nm. Thermogravimetric m...

The highly diastereoselective cascade sequence of three successive thermal pericyclic reactions of 1,2-divinylcyclohexanol allyl and propargyl ethers is described. This novel tandem process provides an efficient synthesis of sesqui- and diterpenoid skeletons having a quaternary carbon at C9. [reaction: see text]